Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5788852..5790547 Replicon chromosome
Accession NZ_CP107275
Organism Pseudomonas aeruginosa strain PALA22

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag PALA22_RS27085 Protein ID WP_003112901.1
Coordinates 5789678..5790547 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag PALA22_RS27080 Protein ID WP_003112902.1
Coordinates 5788852..5789685 (-) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA22_RS27060 (PALA22_05368) 5784083..5785567 - 1485 WP_017001843.1 aldehyde dehydrogenase -
PALA22_RS27065 (PALA22_05369) 5785579..5786382 - 804 WP_003453564.1 aspartate dehydrogenase -
PALA22_RS27070 (PALA22_05370) 5786393..5788075 - 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
PALA22_RS27075 (PALA22_05371) 5788068..5788865 - 798 WP_017001845.1 SDR family oxidoreductase -
PALA22_RS27080 (PALA22_05372) 5788852..5789685 - 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
PALA22_RS27085 (PALA22_05373) 5789678..5790547 - 870 WP_003112901.1 alpha/beta hydrolase Toxin
PALA22_RS27090 (PALA22_05374) 5790556..5791086 - 531 WP_003112900.1 cupin domain-containing protein -
PALA22_RS27095 (PALA22_05375) 5791100..5791861 - 762 WP_003112899.1 SDR family oxidoreductase -
PALA22_RS27100 (PALA22_05376) 5791867..5792643 - 777 WP_003112898.1 ABC transporter permease -
PALA22_RS27105 (PALA22_05377) 5792640..5793647 - 1008 WP_270119291.1 ABC transporter substrate-binding protein -
PALA22_RS27110 (PALA22_05378) 5793688..5794539 - 852 WP_270119294.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T260602 WP_003112901.1 NZ_CP107275:c5790547-5789678 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT260602 WP_003112902.1 NZ_CP107275:c5789685-5788852 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References