Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/-
Location 3851427..3852187 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag STM14_RS19325 Protein ID WP_000533909.1
Coordinates 3851427..3851912 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag STM14_RS19330 Protein ID WP_000965886.1
Coordinates 3851900..3852187 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS19295 (STM14_4394) 3846497..3847159 + 663 WP_000747548.1 OmpA family lipoprotein -
STM14_RS19300 (STM14_4396) 3847378..3848352 + 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
STM14_RS19305 (STM14_4397) 3848402..3849112 - 711 WP_000190524.1 DUF3053 domain-containing protein -
STM14_RS19310 (STM14_4398) 3849551..3849841 + 291 WP_000455790.1 HTH-type transcriptional regulator -
STM14_RS19315 (STM14_4399) 3850130..3850342 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
STM14_RS19320 (STM14_4400) 3850516..3851055 + 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
STM14_RS19325 (STM14_4401) 3851427..3851912 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
STM14_RS19330 (STM14_4402) 3851900..3852187 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
STM14_RS19335 (STM14_4404) 3852365..3852832 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
STM14_RS26190 (STM14_4405) 3853004..3853279 - 276 Protein_3695 IS3 family transposase -
STM14_RS19340 (STM14_4406) 3853461..3855530 - 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
STM14_RS19345 (STM14_4407) 3855540..3856451 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
STM14_RS19350 (STM14_4409) 3856590..3856892 - 303 WP_000605590.1 YsaB family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T26060 WP_000533909.1 NC_016856:c3851912-3851427 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T26060 NC_016856:c3851912-3851427 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT26060 WP_000965886.1 NC_016856:c3852187-3851900 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT26060 NC_016856:c3852187-3851900 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References