260599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4627595..4628637 Replicon chromosome
Accession NZ_CP107275
Organism Pseudomonas aeruginosa strain PALA22

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA22_RS21410 Protein ID WP_003153636.1
Coordinates 4627595..4628170 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA22_RS21415 Protein ID WP_003050245.1
Coordinates 4628167..4628637 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA22_RS21385 (PALA22_04244) 4624033..4624758 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
PALA22_RS21390 (PALA22_04245) 4624797..4625699 - 903 WP_003090158.1 CBASS oligonucleotide cyclase -
PALA22_RS21395 (PALA22_04246) 4625699..4626199 - 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA22_RS21400 (PALA22_04247) 4626196..4626666 - 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA22_RS21405 (PALA22_04248) 4626663..4627577 - 915 WP_003050256.1 AAA family ATPase -
PALA22_RS21410 (PALA22_04249) 4627595..4628170 - 576 WP_003153636.1 PIN domain-containing protein Toxin
PALA22_RS21415 (PALA22_04250) 4628167..4628637 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA22_RS21420 (PALA22_04251) 4628841..4629224 + 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PALA22_RS21425 (PALA22_04252) 4629221..4629454 + 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
PALA22_RS21430 (PALA22_04253) 4629471..4629830 + 360 WP_003090173.1 TIGR03745 family integrating conjugative element membrane protein -
PALA22_RS21435 (PALA22_04254) 4629842..4630240 + 399 WP_009516221.1 TIGR03750 family conjugal transfer protein -
PALA22_RS21440 (PALA22_04255) 4630237..4630929 + 693 WP_009516220.1 TIGR03746 family integrating conjugative element protein -
PALA22_RS21445 (PALA22_04256) 4630926..4631834 + 909 WP_009516219.1 TIGR03749 family integrating conjugative element protein -
PALA22_RS21450 (PALA22_04257) 4631824..4633254 + 1431 WP_033961856.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4581732..4701582 119850


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T260599 WP_003153636.1 NZ_CP107275:c4628170-4627595 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT260599 WP_003050245.1 NZ_CP107275:c4628637-4628167 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References