Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3596654..3597875 Replicon chromosome
Accession NZ_CP107275
Organism Pseudomonas aeruginosa strain PALA22

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag PALA22_RS17035 Protein ID WP_003102740.1
Coordinates 3596654..3597232 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA22_RS17040 Protein ID WP_003088112.1
Coordinates 3597321..3597875 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA22_RS17020 (PALA22_03376) 3591930..3593207 + 1278 WP_003102743.1 TolC family protein -
PALA22_RS17025 (PALA22_03377) 3593197..3595368 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
PALA22_RS17030 (PALA22_03378) 3595358..3596545 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA22_RS17035 (PALA22_03379) 3596654..3597232 - 579 WP_003102740.1 HD domain-containing protein Toxin
PALA22_RS17040 (PALA22_03380) 3597321..3597875 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA22_RS17045 (PALA22_03381) 3598033..3600228 - 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA22_RS17050 (PALA22_03382) 3600233..3600694 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
PALA22_RS17055 (PALA22_03383) 3601025..3601348 + 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA22_RS17060 (PALA22_03384) 3601361..3601759 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA22_RS17065 (PALA22_03385) 3601756..3602307 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T260598 WP_003102740.1 NZ_CP107275:c3597232-3596654 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT260598 WP_003088112.1 NZ_CP107275:c3597875-3597321 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References