Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2627426..2628684 Replicon chromosome
Accession NZ_CP107275
Organism Pseudomonas aeruginosa strain PALA22

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PALA22_RS12425 Protein ID WP_003163133.1
Coordinates 2627929..2628684 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA22_RS12420 Protein ID WP_003086329.1
Coordinates 2627426..2627794 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA22_RS12400 2623589..2623864 + 276 WP_169057979.1 zinc ribbon domain-containing protein -
PALA22_RS12405 (PALA22_02455) 2623867..2624343 - 477 WP_003112531.1 hypothetical protein -
PALA22_RS12410 (PALA22_02456) 2624422..2626011 + 1590 WP_270120740.1 aldehyde dehydrogenase family protein -
PALA22_RS12415 (PALA22_02457) 2626067..2627353 + 1287 WP_270120742.1 FAD-binding oxidoreductase -
PALA22_RS12420 (PALA22_02458) 2627426..2627794 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA22_RS12425 (PALA22_02459) 2627929..2628684 + 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
PALA22_RS12430 (PALA22_02460) 2629451..2630812 + 1362 WP_003081943.1 DNA recombination protein RmuC -
PALA22_RS12435 (PALA22_02461) 2630967..2633510 - 2544 WP_021205057.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T260597 WP_003163133.1 NZ_CP107275:2627929-2628684 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT260597 WP_003086329.1 NZ_CP107275:2627426-2627794 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References