Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 962729..963384 Replicon chromosome
Accession NZ_CP107274
Organism Neisseria gonorrhoeae strain 1145734

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OHM01_RS04985 Protein ID WP_003691083.1
Coordinates 962729..963148 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OHM01_RS04990 Protein ID WP_003688410.1
Coordinates 963148..963384 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM01_RS04965 (OHM01_04965) 957963..959504 - 1542 WP_003701286.1 MDR family MFS transporter -
OHM01_RS04970 (OHM01_04970) 959652..960431 + 780 WP_003688416.1 (Fe-S)-binding protein -
OHM01_RS04975 (OHM01_04975) 960428..961129 + 702 WP_003688414.1 lactate utilization protein C -
OHM01_RS04980 (OHM01_04980) 961126..962580 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OHM01_RS04985 (OHM01_04985) 962729..963148 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OHM01_RS04990 (OHM01_04990) 963148..963384 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OHM01_RS04995 (OHM01_04995) 963832..964410 - 579 WP_003688041.1 IS3 family transposase -
OHM01_RS05000 (OHM01_05000) 964415..964705 - 291 WP_041420764.1 helix-turn-helix domain-containing protein -
OHM01_RS05005 (OHM01_05005) 965055..965441 + 387 Protein_977 transposase -
OHM01_RS05010 (OHM01_05010) 965824..966714 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
OHM01_RS05015 (OHM01_05015) 966725..967891 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
OHM01_RS05020 (OHM01_05020) 967963..968250 - 288 WP_025455945.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T260593 WP_003691083.1 NZ_CP107274:c963148-962729 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT260593 WP_003688410.1 NZ_CP107274:c963384-963148 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References