260589

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 648358..649013 Replicon chromosome
Accession NZ_CP107271
Organism Neisseria gonorrhoeae strain 1123850

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OHM03_RS03505 Protein ID WP_003691083.1
Coordinates 648594..649013 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OHM03_RS03500 Protein ID WP_003688410.1
Coordinates 648358..648594 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHM03_RS03470 (OHM03_03470) 643492..643779 + 288 WP_003688407.1 hypothetical protein -
OHM03_RS03475 (OHM03_03475) 643851..645017 + 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
OHM03_RS03480 (OHM03_03480) 645028..645918 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
OHM03_RS03485 (OHM03_03485) 646301..646687 - 387 Protein_680 transposase -
OHM03_RS03490 (OHM03_03490) 647037..647327 + 291 WP_041420764.1 helix-turn-helix domain-containing protein -
OHM03_RS03495 (OHM03_03495) 647332..647910 + 579 WP_003688041.1 IS3 family transposase -
OHM03_RS03500 (OHM03_03500) 648358..648594 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OHM03_RS03505 (OHM03_03505) 648594..649013 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OHM03_RS03510 (OHM03_03510) 649162..650616 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OHM03_RS03515 (OHM03_03515) 650613..651314 - 702 WP_003688414.1 lactate utilization protein C -
OHM03_RS03520 (OHM03_03520) 651311..652090 - 780 WP_003688416.1 (Fe-S)-binding protein -
OHM03_RS03525 (OHM03_03525) 652238..653779 + 1542 WP_003701286.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T260589 WP_003691083.1 NZ_CP107271:648594-649013 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT260589 WP_003688410.1 NZ_CP107271:648358-648594 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
AlphaFold DB Q5F881

References