Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 768864..769519 Replicon chromosome
Accession NZ_CP107270
Organism Neisseria gonorrhoeae strain 1081168

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OHL99_RS04095 Protein ID WP_003691083.1
Coordinates 769100..769519 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OHL99_RS04090 Protein ID WP_003688410.1
Coordinates 768864..769100 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OHL99_RS04060 (OHL99_04060) 763998..764285 + 288 WP_003688407.1 hypothetical protein -
OHL99_RS04065 (OHL99_04065) 764357..765523 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
OHL99_RS04070 (OHL99_04070) 765534..766424 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
OHL99_RS04075 (OHL99_04075) 766807..767193 - 387 Protein_787 transposase -
OHL99_RS04080 (OHL99_04080) 767543..767833 + 291 WP_041420764.1 helix-turn-helix domain-containing protein -
OHL99_RS04085 (OHL99_04085) 767838..768416 + 579 WP_003688041.1 IS3 family transposase -
OHL99_RS04090 (OHL99_04090) 768864..769100 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OHL99_RS04095 (OHL99_04095) 769100..769519 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OHL99_RS04100 (OHL99_04100) 769668..771122 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OHL99_RS04105 (OHL99_04105) 771119..771820 - 702 WP_003688414.1 lactate utilization protein C -
OHL99_RS04110 (OHL99_04110) 771817..772596 - 780 WP_041421436.1 (Fe-S)-binding protein -
OHL99_RS04115 (OHL99_04115) 772744..774285 + 1542 WP_003697015.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T260588 WP_003691083.1 NZ_CP107270:769100-769519 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT260588 WP_003688410.1 NZ_CP107270:768864-769100 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References