Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 724722..725377 Replicon chromosome
Accession NZ_CP107266
Organism Neisseria gonorrhoeae strain 9112

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDN54_RS03875 Protein ID WP_003691083.1
Coordinates 724958..725377 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDN54_RS03870 Protein ID WP_003688410.1
Coordinates 724722..724958 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDN54_RS03840 (NDN54_03840) 719856..720143 + 288 WP_003688407.1 hypothetical protein -
NDN54_RS03845 (NDN54_03845) 720215..721381 + 1167 WP_003701280.1 ADP-forming succinate--CoA ligase subunit beta -
NDN54_RS03850 (NDN54_03850) 721392..722282 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
NDN54_RS03855 (NDN54_03855) 722665..723051 - 387 Protein_748 IS110 family transposase -
NDN54_RS03860 (NDN54_03860) 723401..723691 + 291 WP_041420764.1 helix-turn-helix domain-containing protein -
NDN54_RS03865 (NDN54_03865) 723696..724274 + 579 WP_003688041.1 IS3 family transposase -
NDN54_RS03870 (NDN54_03870) 724722..724958 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDN54_RS03875 (NDN54_03875) 724958..725377 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDN54_RS03880 (NDN54_03880) 725526..726980 - 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDN54_RS03885 (NDN54_03885) 726977..727678 - 702 WP_003688414.1 lactate utilization protein C -
NDN54_RS03890 (NDN54_03890) 727675..728454 - 780 WP_041421436.1 (Fe-S)-binding protein -
NDN54_RS03895 (NDN54_03895) 728602..730143 + 1542 WP_003697015.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T260585 WP_003691083.1 NZ_CP107266:724958-725377 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT260585 WP_003688410.1 NZ_CP107266:724722-724958 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References