Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 951545..952200 Replicon chromosome
Accession NZ_CP107264
Organism Neisseria gonorrhoeae strain 10231

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag NDN57_RS04895 Protein ID WP_003691083.1
Coordinates 951545..951964 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag NDN57_RS04900 Protein ID WP_003688410.1
Coordinates 951964..952200 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDN57_RS04875 (NDN57_004875) 946779..948320 - 1542 WP_003691084.1 MDR family MFS transporter -
NDN57_RS04880 (NDN57_004880) 948468..949247 + 780 WP_003688416.1 (Fe-S)-binding protein -
NDN57_RS04885 (NDN57_004885) 949244..949945 + 702 WP_003688414.1 lactate utilization protein C -
NDN57_RS04890 (NDN57_004890) 949942..951396 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
NDN57_RS04895 (NDN57_004895) 951545..951964 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
NDN57_RS04900 (NDN57_004900) 951964..952200 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
NDN57_RS04905 (NDN57_004905) 952647..953225 - 579 WP_003697246.1 IS3 family transposase -
NDN57_RS04910 (NDN57_004910) 953230..953520 - 291 WP_047917062.1 helix-turn-helix domain-containing protein -
NDN57_RS04915 (NDN57_004915) 953870..954256 + 387 Protein_965 IS110 family transposase -
NDN57_RS04920 (NDN57_004920) 954639..955529 - 891 WP_229930257.1 succinate--CoA ligase subunit alpha -
NDN57_RS04925 (NDN57_004925) 955540..956706 - 1167 WP_003699872.1 ADP-forming succinate--CoA ligase subunit beta -
NDN57_RS04930 (NDN57_004930) 956778..957065 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T260583 WP_003691083.1 NZ_CP107264:c951964-951545 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT260583 WP_003688410.1 NZ_CP107264:c952200-951964 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References