Detailed information of TA system TA260572

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2037838..2039521
• Replicon: chromosome
• Accession: NZ_CP107262
• Organism: Leclercia adecarboxylata strain 2022CK-00320

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: N5937_RS10390
• Protein ID: WP_103178138.1
• Coordinates: 2038604..2039521 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: N5937_RS10385
• Protein ID: WP_103178139.1
• Coordinates: 2037838..2038611 (+)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N5937_RS10360 (2033279)	2033279..2033659	+	381	WP_103178144.1	5-carboxymethyl-2-hydroxymuconate Delta-isomerase	-
N5937_RS10365 (2033861)	2033861..2034664	+	804	WP_103823153.1	2-oxo-hepta-3-ene-1,7-dioic acid hydratase	-
N5937_RS10370 (2034675)	2034675..2035472	+	798	WP_263951466.1	4-hydroxy-2-oxoheptanedioate aldolase	-
N5937_RS10375 (2035490)	2035490..2036836	+	1347	WP_263951467.1	4-hydroxyphenylacetate permease	-
N5937_RS10380 (2036846)	2036846..2037736	+	891	WP_263951468.1	4-hydroxyphenylacetate catabolism regulatory protein HpaA	-
N5937_RS10385 (2037838)	2037838..2038611	+	774	WP_103178139.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
N5937_RS10390 (2038604)	2038604..2039521	+	918	WP_103178138.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
N5937_RS10395 (2039754)	2039754..2041316	+	1563	WP_263951469.1	4-hydroxyphenylacetate 3-monooxygenase, oxygenase component	-
N5937_RS10400 (2041334)	2041334..2041846	+	513	WP_263951470.1	4-hydroxyphenylacetate 3-monooxygenase reductase subunit	-
N5937_RS10405 (2042337)	2042337..2042711	+	375	WP_263951471.1	hypothetical protein	-
N5937_RS10410 (2042729)	2042729..2044492	+	1764	WP_263951472.1	polysaccharide biosynthesis/export family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2037838..2055172	17334

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34678.72 Da
• Isoelectric Point: 5.6629

>T260572 WP_103178138.1 NZ_CP107262:2038604-2039521 [Leclercia adecarboxylata]
MDRTSPYHRQVALLVRALPYVANESCFALKGGTAINLFIHNFPRLSVDIDLAYIPLESREVALPNVRDALTRIANELEAQ
SGISAVLQTNNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDVVETVEDEFGFAAIPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRAIFNGFIAYLLSHNRPLSEVLSPRWKDITGPFQNEFNGMTIQDVSLKELVNVPERMLNALKE
HFTHQDFDFLMSFKRGAPDWNLAPESPIQHLPAVQWKLRNISRMSEEKRAQSLKKLERVLEKWIS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 29235.42 Da
• Isoelectric Point: 9.5590

>AT260572 WP_103178139.1 NZ_CP107262:2037838-2038611 [Leclercia adecarboxylata]
MSSKLNWLLQNTSPGSLVLQSWLTRNDISPSLAFKYAQNGWLNKLRAGVYARAGREPDWSDALECLQNQLAAPVYLAGLT
SLSWQGRSHYLQLNQSQCWLSAENKTLLPKWFKEFPDVDWRVVSGLKLPQLDEKYRTELEIKGKKLTASGPELATYELLS
AVPQDISFEHAAELFQGLVNLNPRKIESLLVLSQAVQTKRLYLFFASFYEHAWLKRIDISKIDLGSGNRQIVANGKLNTQ
YQITVPENFNLKGRNYG

Nucleotide

• Length: 774 bp