Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1877250..1878818 Replicon chromosome
Accession NZ_CP107262
Organism Leclercia adecarboxylata strain 2022CK-00320

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5937_RS09475 Protein ID WP_000783857.1
Coordinates 1877250..1878563 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A859R2S1
Locus tag N5937_RS09480 Protein ID WP_039272366.1
Coordinates 1878567..1878818 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5937_RS09455 (1873133) 1873133..1873435 + 303 WP_031611417.1 hypothetical protein -
N5937_RS09460 (1873807) 1873807..1875447 - 1641 WP_031611419.1 PAAR domain-containing protein -
N5937_RS09465 (1875646) 1875646..1876584 + 939 WP_044596315.1 hypothetical protein -
N5937_RS09470 (1876759) 1876759..1877253 - 495 WP_039272364.1 hypothetical protein -
N5937_RS09475 (1877250) 1877250..1878563 - 1314 WP_000783857.1 type II toxin-antitoxin system HipA family toxin Toxin
N5937_RS09480 (1878567) 1878567..1878818 - 252 WP_039272366.1 helix-turn-helix domain-containing protein Antitoxin
N5937_RS09485 (1879183) 1879183..1880187 - 1005 WP_039272368.1 tyrosine-type recombinase/integrase -
N5937_RS09490 (1880190) 1880190..1880753 - 564 WP_001132404.1 hypothetical protein -
N5937_RS09495 (1880772) 1880772..1881053 - 282 WP_000575656.1 hypothetical protein -
N5937_RS09500 (1881314) 1881314..1881916 + 603 WP_039272372.1 hypothetical protein -
N5937_RS09505 (1881932) 1881932..1882384 - 453 WP_001553092.1 hypothetical protein -
N5937_RS09510 (1882440) 1882440..1883165 - 726 WP_001553093.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element catB2 / ant(3'')-Ia / aph(3')-XV / blaVIM-1 / blaSHV-12 / mph(A) / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / qnrS1 - 1792450..2003486 211036


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-64)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48209.48 Da        Isoelectric Point: 6.4189

>T260571 WP_000783857.1 NZ_CP107262:c1878563-1877250 [Leclercia adecarboxylata]
MKMQTLTVAMNGEVVGTLYRDNKGAMSFQYAPEWISEPGSRAISMSLPLGHGRITGSEVFNFFSNLLPDSEAIIARMQAR
FRVETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDEAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTA
LLWYQDRWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKKKVLVVQRFDRRWS
KSGEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEP
ASSFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYHFAMIQPRHFISTAAHVGFPQDTAAQLMFDMATKTEEV
VATVAAELPAGFPEHISSAIFEGLSSQAAKILKGVAK

Download         Length: 1314 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9369.79 Da        Isoelectric Point: 9.8930

>AT260571 WP_039272366.1 NZ_CP107262:c1878818-1878567 [Leclercia adecarboxylata]
MKVTSPSLLAAAVRDQRKLSKLTQSEAAKQVGIKQTTVSDFELRPESTKLETLFKLLSALDLELHVVKRGSTLDDSKVWD
REW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A859R2S1

References