Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1383193..1383812 Replicon chromosome
Accession NZ_CP107262
Organism Leclercia adecarboxylata strain 2022CK-00320

Toxin (Protein)


Gene name Hha Uniprot ID A0A345CDT0
Locus tag N5937_RS07110 Protein ID WP_032616864.1
Coordinates 1383594..1383812 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag N5937_RS07105 Protein ID WP_103178503.1
Coordinates 1383193..1383585 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5937_RS07095 (1378347) 1378347..1379540 + 1194 WP_156654007.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N5937_RS07100 (1379563) 1379563..1382703 + 3141 WP_103178504.1 multidrug efflux RND transporter permease subunit AcrB -
N5937_RS07105 (1383193) 1383193..1383585 + 393 WP_103178503.1 Hha toxicity modulator TomB Antitoxin
N5937_RS07110 (1383594) 1383594..1383812 + 219 WP_032616864.1 HHA domain-containing protein Toxin
N5937_RS07115 (1384076) 1384076..1384540 + 465 WP_103178502.1 YlaC family protein -
N5937_RS07120 (1384590) 1384590..1384730 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
N5937_RS07125 (1384988) 1384988..1386556 + 1569 WP_263951259.1 EAL domain-containing protein -
N5937_RS07130 (1386589) 1386589..1386942 - 354 WP_103178500.1 DUF1428 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T260570 WP_032616864.1 NZ_CP107262:1383594-1383812 [Leclercia adecarboxylata]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15150.05 Da        Isoelectric Point: 4.8941

>AT260570 WP_103178503.1 NZ_CP107262:1383193-1383585 [Leclercia adecarboxylata]
MDEYSPKRQDIAQLKFLCESLYHDCLTNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNASRANPLASPIKIITNN

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345CDT0

Antitoxin

Source ID Structure

References