Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3225147..3225807 Replicon
Accession NC_016856
Organism Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag STM14_RS16280 Protein ID WP_000244756.1
Coordinates 3225147..3225560 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag STM14_RS16285 Protein ID WP_000351186.1
Coordinates 3225541..3225807 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STM14_RS16260 (STM14_3674) 3221088..3222821 - 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -
STM14_RS16265 (STM14_3675) 3222827..3223540 - 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
STM14_RS16270 (STM14_3676) 3223564..3224460 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
STM14_RS16275 (STM14_3677) 3224573..3225094 + 522 WP_001055885.1 flavodoxin FldB -
STM14_RS16280 (STM14_3678) 3225147..3225560 - 414 WP_000244756.1 protein YgfX Toxin
STM14_RS16285 (STM14_3679) 3225541..3225807 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
STM14_RS16295 (STM14_3681) 3226057..3227037 + 981 WP_000874172.1 tRNA-modifying protein YgfZ -
STM14_RS16300 (STM14_3682) 3227153..3227812 - 660 WP_000250289.1 hemolysin III family protein -
STM14_RS16305 (STM14_3683) 3227976..3228287 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
STM14_RS16310 (STM14_3684) 3228446..3229879 + 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T26057 WP_000244756.1 NC_016856:c3225560-3225147 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T26057 NC_016856:c3225560-3225147 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT26057 WP_000351186.1 NC_016856:c3225807-3225541 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT26057 NC_016856:c3225807-3225541 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References