Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 219900..221462 Replicon chromosome
Accession NZ_CP107262
Organism Leclercia adecarboxylata strain 2022CK-00320

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5937_RS01405 Protein ID WP_103179601.1
Coordinates 220155..221462 (+) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N5937_RS01400 Protein ID WP_103179602.1
Coordinates 219900..220151 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5937_RS01395 (215294) 215294..219085 - 3792 WP_263950834.1 glycosyltransferase -
N5937_RS01400 (219900) 219900..220151 + 252 WP_103179602.1 helix-turn-helix domain-containing protein Antitoxin
N5937_RS01405 (220155) 220155..221462 + 1308 WP_103179601.1 type II toxin-antitoxin system HipA family toxin Toxin
N5937_RS01410 (221568) 221568..222629 + 1062 WP_103179600.1 YncE family protein -
N5937_RS01415 (222640) 222640..224634 + 1995 WP_263950835.1 TonB-dependent receptor -
N5937_RS01420 (224768) 224768..225949 + 1182 WP_263950836.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 48550.90 Da        Isoelectric Point: 6.8300

>T260568 WP_103179601.1 NZ_CP107262:220155-221462 [Leclercia adecarboxylata]
MRAQRLTVAMNGEVVGTLHRDGSGAMSFQYAPEWLAEPGARAISLSLPLQHGRIRGKQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGLEIPSVMDIVAEPLDDEQIASLLEGYQMAPLGMSEEGADFRISLAGAQEKT
ALLWYQDRWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAHAEMATFSRKKVLIIERFDRRW
ARSGWLMRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAQDREMFFKAQILFWMLAAIDGHGKNFSLFIEA
DSSFRMAPLYDVISAFPLFEAGSIPAKKAKMAMALQGKNRQYHFAMIQPRHFISTAAHAGFSQEIARRLMKEMADRTDEA
IATVRAELPADFPEQISEAIFRGLVSQAARISRFD

Download         Length: 1308 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9265.55 Da        Isoelectric Point: 8.6793

>AT260568 WP_103179602.1 NZ_CP107262:219900-220151 [Leclercia adecarboxylata]
MKVTSAGALAQAVKDQRKVNKLTQSETAEQVGIKQTTVSDFENKPESTKLETLFKILSALDLELHVVKRGSTLPDHANWT
KEW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References