260567

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 5970605..5972109 Replicon chromosome
Accession NZ_CP107257
Organism Pseudomonas aeruginosa strain 2019CK-00034

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag N5938_RS28360 Protein ID WP_003119682.1
Coordinates 5971522..5972109 (-) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A9E8LAI1
Locus tag N5938_RS28355 Protein ID WP_003117606.1
Coordinates 5970605..5971459 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5938_RS28340 (N5938_28340) 5966024..5966233 + 210 WP_003091604.1 cold-shock protein -
N5938_RS28345 (N5938_28345) 5966294..5968168 - 1875 WP_003117607.1 MFS transporter -
N5938_RS28350 (N5938_28350) 5968343..5970508 - 2166 WP_033989266.1 TonB-dependent receptor family protein -
N5938_RS28355 (N5938_28355) 5970605..5971459 - 855 WP_003117606.1 AraC family transcriptional regulator Antitoxin
N5938_RS28360 (N5938_28360) 5971522..5972109 - 588 WP_003119682.1 GNAT family protein Toxin
N5938_RS28365 (N5938_28365) 5972375..5975854 + 3480 WP_116819943.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T260567 WP_003119682.1 NZ_CP107257:c5972109-5971522 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31863.14 Da        Isoelectric Point: 7.5295

>AT260567 WP_003117606.1 NZ_CP107257:c5971459-5970605 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References