260566

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4087233..4088453 Replicon chromosome
Accession NZ_CP107257
Organism Pseudomonas aeruginosa strain 2019CK-00034

Toxin (Protein)


Gene name vapC Uniprot ID V6AG16
Locus tag N5938_RS19445 Protein ID WP_003088107.1
Coordinates 4087233..4087811 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag N5938_RS19450 Protein ID WP_003132728.1
Coordinates 4087899..4088453 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5938_RS19430 (N5938_19430) 4082509..4083786 + 1278 WP_003088104.1 TolC family protein -
N5938_RS19435 (N5938_19435) 4083776..4085947 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
N5938_RS19440 (N5938_19440) 4085937..4087124 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
N5938_RS19445 (N5938_19445) 4087233..4087811 - 579 WP_003088107.1 HD domain-containing protein Toxin
N5938_RS19450 (N5938_19450) 4087899..4088453 - 555 WP_003132728.1 helix-turn-helix transcriptional regulator Antitoxin
N5938_RS19455 (N5938_19455) 4088611..4090806 - 2196 WP_034027441.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
N5938_RS19460 (N5938_19460) 4090811..4091272 - 462 WP_003088117.1 (2Fe-2S)-binding protein -
N5938_RS19465 (N5938_19465) 4091603..4091926 + 324 WP_003102734.1 multidrug efflux SMR transporter -
N5938_RS19470 (N5938_19470) 4091939..4092337 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
N5938_RS19475 (N5938_19475) 4092334..4092885 - 552 WP_003132721.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-187)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21885.74 Da        Isoelectric Point: 5.3655

>T260566 WP_003088107.1 NZ_CP107257:c4087811-4087233 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20470.63 Da        Isoelectric Point: 8.1590

>AT260566 WP_003132728.1 NZ_CP107257:c4088453-4087899 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AG16

Antitoxin

Source ID Structure

References