260565

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 3032799..3034057 Replicon chromosome
Accession NZ_CP107257
Organism Pseudomonas aeruginosa strain 2019CK-00034

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag N5938_RS14355 Protein ID WP_031636480.1
Coordinates 3033302..3034057 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag N5938_RS14350 Protein ID WP_003086329.1
Coordinates 3032799..3033167 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5938_RS14330 (N5938_14330) 3028977..3029237 + 261 WP_023095977.1 zinc ribbon domain-containing protein -
N5938_RS14335 (N5938_14335) 3029240..3029716 - 477 WP_003086322.1 hypothetical protein -
N5938_RS14340 (N5938_14340) 3029795..3031384 + 1590 WP_116819605.1 aldehyde dehydrogenase family protein -
N5938_RS14345 (N5938_14345) 3031440..3032726 + 1287 WP_116819604.1 FAD-binding oxidoreductase -
N5938_RS14350 (N5938_14350) 3032799..3033167 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
N5938_RS14355 (N5938_14355) 3033302..3034057 + 756 WP_031636480.1 RES family NAD+ phosphorylase Toxin
N5938_RS14360 (N5938_14360) 3034827..3036188 + 1362 WP_003081943.1 DNA recombination protein RmuC -
N5938_RS14365 (N5938_14365) 3036343..3038886 - 2544 WP_116819603.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28264.36 Da        Isoelectric Point: 7.7297

>T260565 WP_031636480.1 NZ_CP107257:3033302-3034057 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALRLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT260565 WP_003086329.1 NZ_CP107257:3032799-3033167 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References