260564

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2547353..2547926 Replicon chromosome
Accession NZ_CP107257
Organism Pseudomonas aeruginosa strain 2019CK-00034

Toxin (Protein)


Gene name relE Uniprot ID W5IUR0
Locus tag N5938_RS11825 Protein ID WP_009618209.1
Coordinates 2547639..2547926 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID W5ISI7
Locus tag N5938_RS11820 Protein ID WP_009618210.1
Coordinates 2547353..2547652 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5938_RS11790 (N5938_11790) 2542455..2542673 + 219 WP_011829925.1 AlpA family transcriptional regulator -
N5938_RS11795 (N5938_11795) 2542714..2543581 + 868 Protein_2315 ParA family protein -
N5938_RS11800 (N5938_11800) 2543565..2543801 + 237 WP_013982111.1 type II toxin-antitoxin system HicA family toxin -
N5938_RS11805 (N5938_11805) 2543794..2545451 + 1658 Protein_2317 ParB family protein -
N5938_RS11810 (N5938_11810) 2545469..2546029 + 561 WP_018076214.1 DUF2857 domain-containing protein -
N5938_RS11815 (N5938_11815) 2546032..2547251 + 1220 Protein_2319 STY4528 family pathogenicity island replication protein -
N5938_RS11820 (N5938_11820) 2547353..2547652 + 300 WP_009618210.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N5938_RS11825 (N5938_11825) 2547639..2547926 + 288 WP_009618209.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5938_RS11830 (N5938_11830) 2547955..2548146 + 192 WP_011805449.1 hypothetical protein -
N5938_RS11835 (N5938_11835) 2548270..2549049 + 780 WP_017244811.1 TIGR03761 family integrating conjugative element protein -
N5938_RS11840 (N5938_11840) 2549030..2549593 + 564 WP_263901907.1 DUF3158 family protein -
N5938_RS11845 (N5938_11845) 2549590..2550039 + 450 WP_119163122.1 single-stranded DNA-binding protein -
N5938_RS11850 (N5938_11850) 2550322..2552337 + 2016 WP_003141052.1 DNA topoisomerase III -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-58)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10854.46 Da        Isoelectric Point: 8.4628

>T260564 WP_009618209.1 NZ_CP107257:2547639-2547926 [Pseudomonas aeruginosa]
VRVLEWREAARADLLAIVDYISDDNPDAAQRLKDDIEAKAAKLPERPKLYRPGRVAGTREMVVRANYVVVYMEDTRAVSI
LRVLHAAQQWPPARE

Download         Length: 288 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10816.46 Da        Isoelectric Point: 8.6579

>AT260564 WP_009618210.1 NZ_CP107257:2547353-2547652 [Pseudomonas aeruginosa]
MAAQTSMLHIRVDDKLKADAAEKLAGVGLTVSDAVRILLTRVVKEGALPAGLTADPEAYDAWFRAKVQEALADTRPPVPH
QQVMDEAQALIDRKRRART

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5R9QF16

Antitoxin

Source ID Structure
AlphaFold DB A0A5R9QE11

References