260562

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 789358..789863 Replicon chromosome
Accession NZ_CP107257
Organism Pseudomonas aeruginosa strain 2019CK-00034

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag N5938_RS03725 Protein ID WP_003083773.1
Coordinates 789582..789863 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag N5938_RS03720 Protein ID WP_003083775.1
Coordinates 789358..789585 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5938_RS03695 (N5938_03695) 784388..785881 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
N5938_RS03700 (N5938_03700) 786050..787465 + 1416 WP_263901831.1 GABA permease -
N5938_RS03705 (N5938_03705) 787547..787888 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
N5938_RS03710 (N5938_03710) 787961..788461 - 501 WP_003101228.1 LEA type 2 family protein -
N5938_RS03715 (N5938_03715) 788562..789182 + 621 WP_023092259.1 hypothetical protein -
N5938_RS03720 (N5938_03720) 789358..789585 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
N5938_RS03725 (N5938_03725) 789582..789863 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
N5938_RS03730 (N5938_03730) 790163..791071 + 909 WP_003083769.1 LysR family transcriptional regulator -
N5938_RS03735 (N5938_03735) 791103..791513 - 411 WP_003110659.1 aegerolysin family protein -
N5938_RS03740 (N5938_03740) 791693..792427 - 735 WP_003083764.1 GntR family transcriptional regulator -
N5938_RS03745 (N5938_03745) 792528..793214 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
N5938_RS03750 (N5938_03750) 793263..794612 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T260562 WP_003083773.1 NZ_CP107257:789582-789863 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT260562 WP_003083775.1 NZ_CP107257:789358-789585 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References