Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 5837762..5839379 Replicon chromosome
Accession NZ_CP107244
Organism Achromobacter sp. SS2-2022

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N3Z32_RS26195 Protein ID WP_268080213.1
Coordinates 5837762..5839075 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag N3Z32_RS26200 Protein ID WP_268080214.1
Coordinates 5839119..5839379 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N3Z32_RS26175 (N3Z32_26195) 5833318..5834745 + 1428 WP_268080207.1 basic amino acid/polyamine antiporter -
N3Z32_RS26180 (N3Z32_26200) 5834763..5836586 + 1824 WP_268080209.1 SLC13 family permease -
N3Z32_RS26185 (N3Z32_26205) 5836711..5837190 + 480 WP_268080211.1 hypothetical protein -
N3Z32_RS26190 (N3Z32_26210) 5837240..5837731 + 492 WP_268080212.1 hypothetical protein -
N3Z32_RS26195 (N3Z32_26215) 5837762..5839075 - 1314 WP_268080213.1 type II toxin-antitoxin system HipA family toxin Toxin
N3Z32_RS26200 (N3Z32_26220) 5839119..5839379 - 261 WP_268080214.1 helix-turn-helix transcriptional regulator Antitoxin
N3Z32_RS26205 (N3Z32_26225) 5839566..5840663 - 1098 WP_268080215.1 DUF3396 domain-containing protein -
N3Z32_RS26210 (N3Z32_26230) 5840672..5841313 - 642 WP_268080216.1 VRR-NUC domain-containing protein -
N3Z32_RS26215 (N3Z32_26235) 5841310..5841816 - 507 WP_268080217.1 PAAR domain-containing protein -
N3Z32_RS26220 (N3Z32_26240) 5841869..5842300 - 432 Protein_5173 integrase core domain-containing protein -
N3Z32_RS26225 (N3Z32_26245) 5842581..5843261 - 681 WP_268080218.1 hypothetical protein -
N3Z32_RS26230 (N3Z32_26250) 5843837..5844232 - 396 WP_268080220.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(1-98)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 48540.60 Da        Isoelectric Point: 6.7741

>T260559 WP_268080213.1 NZ_CP107244:c5839075-5837762 [Achromobacter sp. SS2-2022]
MNGEFVGTWSVQPHVGEVLQYADAWVASGQGRPLSLSLPFTPGNPPHRGEAVRTYFENLLPDSKEIRERVARRYQAGSTN
AFALLAEVGRDCVGALQVVPGPDAPDGVQEVNAVPMTDAEIAQLLRNTLAPGPLGRNAAEDEDFRISIAGAQEKSAMLWY
DGRWCRPHGATPTTHIFKLPLGLVANMKFDMSDSVENEWLCSEILRAYQMPVARTEPLMFEDMKVLAVERFDRMWWESPE
GKRWLIRLPQEDMCQATATPPHLKYESDGGPGVRQIMKLLATSRAPDRDRRTFFQAQVLFWMLRATDGHAKNFSIFLRQG
GTYELTPLYDVLSAYPVIGKGAKKLSPYDAKMAMAVRSKNPHWVMRDILRRHWIAVGTEHGVVNPDGKGVEHVLDDLVAR
TPGVVKAVRALLPAGFPMHVADCILNGLQEAADHLAG

Download         Length: 1314 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9398.77 Da        Isoelectric Point: 8.8776

>AT260559 WP_268080214.1 NZ_CP107244:c5839379-5839119 [Achromobacter sp. SS2-2022]
MTDFTVRTAEQLPALLQGFRKQSGLTQADTAMRLGVSQQALSHLERHADKVSADRLLELLSILGVELVLRKTSESPSPKA
SVGPNW

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References