Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4697606..4698230 Replicon chromosome
Accession NZ_CP107244
Organism Achromobacter sp. SS2-2022

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag N3Z32_RS21105 Protein ID WP_268079350.1
Coordinates 4697606..4697788 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N3Z32_RS21110 Protein ID WP_268079351.1
Coordinates 4697838..4698230 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N3Z32_RS21075 (N3Z32_21090) 4693417..4694286 - 870 WP_268079346.1 alpha/beta hydrolase -
N3Z32_RS21080 (N3Z32_21095) 4694537..4695454 - 918 WP_268079347.1 DUF808 domain-containing protein -
N3Z32_RS21085 (N3Z32_21100) 4695647..4695904 - 258 WP_259251979.1 hypothetical protein -
N3Z32_RS21090 (N3Z32_21105) 4695973..4696176 - 204 WP_050448526.1 cold-shock protein -
N3Z32_RS21095 (N3Z32_21110) 4696640..4697077 + 438 WP_268079348.1 hypothetical protein -
N3Z32_RS21100 (N3Z32_21115) 4697096..4697437 - 342 WP_268079349.1 hypothetical protein -
N3Z32_RS21105 (N3Z32_21120) 4697606..4697788 + 183 WP_268079350.1 type II toxin-antitoxin system HicA family toxin Toxin
N3Z32_RS21110 (N3Z32_21125) 4697838..4698230 + 393 WP_268079351.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
N3Z32_RS21115 (N3Z32_21130) 4698271..4699011 - 741 WP_268079352.1 SDR family oxidoreductase -
N3Z32_RS21120 (N3Z32_21135) 4699049..4700389 - 1341 WP_277549605.1 CitMHS family transporter -
N3Z32_RS21125 (N3Z32_21140) 4700579..4701283 + 705 WP_268079353.1 response regulator transcription factor -
N3Z32_RS21130 (N3Z32_21145) 4701287..4702741 + 1455 WP_268079354.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6765.99 Da        Isoelectric Point: 12.1585

>T260558 WP_268079350.1 NZ_CP107244:4697606-4697788 [Achromobacter sp. SS2-2022]
MNSREIIRQLRQAGWVFRHAKGSHHIFVHPQKPGHISVPHPKKDLGIGLVTKLLTQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 13915.77 Da        Isoelectric Point: 4.2687

>AT260558 WP_268079351.1 NZ_CP107244:4697838-4698230 [Achromobacter sp. SS2-2022]
MKYPIAIEPGSETQAWGVVVPDLPGCFSAADSGIDEAIENAKEAIELWIETALDSGTPVPVATSIAGHQANPEFAGWIWA
IVEIDPAVMDDTIERINITLPRRILARIDAKARAAGESRSGYIAHLALTH

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References