Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 1361..1824 Replicon plasmid pjD1
Accession NZ_CP107224
Organism Neisseria gonorrhoeae strain H035

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag OE961_RS11465 Protein ID WP_003690225.1
Coordinates 1546..1824 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag OE961_RS11460 Protein ID WP_003690223.1
Coordinates 1361..1546 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE961_RS11445 (OE961_11445) 1..870 + 870 WP_003690219.1 replication initiation protein -
OE961_RS11450 (OE961_11450) 874..1116 + 243 WP_003690220.1 HTH domain-containing protein -
OE961_RS11455 (OE961_11455) 1113..1358 + 246 WP_003690221.1 hypothetical protein -
OE961_RS11460 (OE961_11460) 1361..1546 + 186 WP_003690223.1 DUF5397 family protein Antitoxin
OE961_RS11465 (OE961_11465) 1546..1824 + 279 WP_003690225.1 endoribonuclease VapD Toxin
OE961_RS11470 (OE961_11470) 1802..2056 - 255 WP_003690227.1 Cryptic plasmid protein A -
OE961_RS11475 (OE961_11475) 2103..2690 - 588 WP_003692168.1 MbeB family mobilization protein -
OE961_RS11480 (OE961_11480) 2774..3403 - 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
OE961_RS11485 (OE961_11485) 3388..3768 - 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4153 4153


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T260547 WP_003690225.1 NZ_CP107224:1546-1824 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT260547 WP_003690223.1 NZ_CP107224:1361-1546 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References