Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 723347..724002 Replicon chromosome
Accession NZ_CP107223
Organism Neisseria gonorrhoeae strain H035

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag OE961_RS03865 Protein ID WP_003691083.1
Coordinates 723583..724002 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag OE961_RS03860 Protein ID WP_003688410.1
Coordinates 723347..723583 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OE961_RS03830 (OE961_03830) 718481..718768 + 288 WP_003688407.1 hypothetical protein -
OE961_RS03835 (OE961_03835) 718840..720006 + 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
OE961_RS03840 (OE961_03840) 720017..720907 + 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
OE961_RS03845 (OE961_03845) 721290..721676 - 387 Protein_745 transposase -
OE961_RS03850 (OE961_03850) 722026..722316 + 291 WP_041420764.1 helix-turn-helix domain-containing protein -
OE961_RS03855 (OE961_03855) 722321..722899 + 579 WP_003688041.1 IS3 family transposase -
OE961_RS03860 (OE961_03860) 723347..723583 + 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
OE961_RS03865 (OE961_03865) 723583..724002 + 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
OE961_RS03870 (OE961_03870) 724151..725605 - 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
OE961_RS03875 (OE961_03875) 725602..726303 - 702 WP_003688414.1 lactate utilization protein C -
OE961_RS03880 (OE961_03880) 726300..727079 - 780 WP_003688416.1 (Fe-S)-binding protein -
OE961_RS03885 (OE961_03885) 727227..728768 + 1542 WP_003701286.1 MDR family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T260546 WP_003691083.1 NZ_CP107223:723583-724002 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT260546 WP_003688410.1 NZ_CP107223:723347-723583 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References