260519

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1330626..1331542 Replicon chromosome
Accession NZ_CP107079
Organism Bacillus velezensis strain LT-2

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag OD347_RS07070 Protein ID WP_088612661.1
Coordinates 1330796..1331542 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag OD347_RS07065 Protein ID WP_003154807.1
Coordinates 1330626..1330796 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OD347_RS07030 1327536..1327868 + 333 WP_088612657.1 XkdW family protein -
OD347_RS07035 1327868..1328032 + 165 WP_014470494.1 XkdX family protein -
OD347_RS07040 1328087..1328884 + 798 WP_088612658.1 phage portal protein -
OD347_RS07045 1328938..1329201 + 264 WP_088612659.1 hemolysin XhlA family protein -
OD347_RS07050 1329215..1329478 + 264 WP_013351965.1 phage holin -
OD347_RS07055 1329492..1330370 + 879 WP_088612660.1 N-acetylmuramoyl-L-alanine amidase -
OD347_RS07060 1330404..1330529 - 126 WP_003154809.1 hypothetical protein -
OD347_RS07065 1330626..1330796 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
OD347_RS07070 1330796..1331542 - 747 WP_088612661.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OD347_RS07075 1331651..1332649 - 999 WP_013351968.1 inorganic phosphate transporter -
OD347_RS07080 1332662..1333279 - 618 WP_003154804.1 DUF47 domain-containing protein -
OD347_RS07085 1333564..1334880 - 1317 WP_088612662.1 amino acid permease -
OD347_RS07090 1335202..1336152 + 951 WP_013351970.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29084.56 Da        Isoelectric Point: 4.6839

>T260519 WP_088612661.1 NZ_CP107079:c1331542-1330796 [Bacillus velezensis]
MLLFYQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFTAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRQYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT260519 WP_003154807.1 NZ_CP107079:c1330796-1330626 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References