Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 9557..10200 Replicon plasmid unnamed1
Accession NZ_CP107078
Organism Kosakonia cowanii strain LT-1

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag ODS25_RS22025 Protein ID WP_263754817.1
Coordinates 9784..10200 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag ODS25_RS22020 Protein ID WP_200581138.1
Coordinates 9557..9787 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ODS25_RS21990 5231..5581 - 351 WP_263754812.1 hypothetical protein -
ODS25_RS21995 5656..5916 - 261 WP_263754813.1 hypothetical protein -
ODS25_RS22000 6119..6631 + 513 WP_000151784.1 hypothetical protein -
ODS25_RS22005 6665..7798 - 1134 WP_000545987.1 DUF3800 domain-containing protein -
ODS25_RS22010 7965..8738 - 774 WP_000905949.1 hypothetical protein -
ODS25_RS22015 8751..9251 - 501 WP_263754815.1 HEPN family nuclease -
ODS25_RS22020 9557..9787 + 231 WP_200581138.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
ODS25_RS22025 9784..10200 + 417 WP_263754817.1 type II toxin-antitoxin system VapC family toxin Toxin
ODS25_RS22030 10356..11336 + 981 WP_263754819.1 hypothetical protein -
ODS25_RS22035 11548..13119 - 1572 WP_263754821.1 AAA family ATPase -
ODS25_RS22040 13306..13494 - 189 WP_263754822.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80130 80130
- flank IS/Tn - - 13597..15396 1799


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15260.60 Da        Isoelectric Point: 6.2251

>T260517 WP_263754817.1 NZ_CP107078:9784-10200 [Kosakonia cowanii]
VNKTYMLDTCICSFIMREQPEAVLKRLEQEVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVEEFCARLDAVLPWDRC
AVDATTEIRVALRLAGTPIGPNDTAIAGHAIATGAVLVTNNVREFERVPGLTLEDWVN

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8866.00 Da        Isoelectric Point: 4.4076

>AT260517 WP_200581138.1 NZ_CP107078:9557-9787 [Kosakonia cowanii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWRSFLELEKADPDFMAEREDVVSDEGRFDL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References