Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4612151..4612764 Replicon chromosome
Accession NZ_CP107077
Organism Kosakonia cowanii strain LT-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ODS25_RS21600 Protein ID WP_242389198.1
Coordinates 4612151..4612519 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ODS25_RS21605 Protein ID WP_042712315.1
Coordinates 4612522..4612764 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ODS25_RS21585 4609652..4610554 + 903 WP_023479333.1 formate dehydrogenase subunit beta -
ODS25_RS21590 4610551..4611189 + 639 WP_263753594.1 formate dehydrogenase cytochrome b556 subunit -
ODS25_RS21595 4611186..4612115 + 930 WP_023479362.1 formate dehydrogenase accessory protein FdhE -
ODS25_RS21600 4612151..4612519 - 369 WP_242389198.1 type II toxin-antitoxin system VapC family toxin Toxin
ODS25_RS21605 4612522..4612764 - 243 WP_042712315.1 CopG family transcriptional regulator Antitoxin
ODS25_RS21610 4612966..4613877 + 912 WP_263753595.1 alpha/beta hydrolase -
ODS25_RS21615 4613931..4614872 - 942 WP_023479318.1 fatty acid biosynthesis protein FabY -
ODS25_RS21620 4614917..4615351 - 435 WP_023479361.1 D-aminoacyl-tRNA deacylase -
ODS25_RS21625 4615348..4616220 - 873 WP_263753596.1 virulence factor BrkB family protein -
ODS25_RS21630 4616217..4616813 - 597 WP_263753597.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13727.72 Da        Isoelectric Point: 4.8667

>T260516 WP_242389198.1 NZ_CP107077:c4612519-4612151 [Kosakonia cowanii]
MSNLALFDTNILIDLFNGREEAANTFEDYNGRIAISLISWIEVLVGAKKVGQENATRDFLDSLEVIEISHPIAERSIELR
QAYRMKLPDAIILATAQIHSRCLVTRNIKDFASVTGVFTPYQ

Download         Length: 369 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9241.47 Da        Isoelectric Point: 4.5230

>AT260516 WP_042712315.1 NZ_CP107077:c4612764-4612522 [Kosakonia cowanii]
MDVLSGVIMGRILLDLSDDVIRRLDSLKQQRNLPRAELLREAVEQYLEKQNTTSARNALGLWGGEGEDGLEFERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References