260503

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 6078909..6079951 Replicon chromosome
Accession NZ_CP107064
Organism Pseudomonas aeruginosa strain PALA20

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag PALA20_RS28590 Protein ID WP_003153636.1
Coordinates 6078909..6079484 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag PALA20_RS28595 Protein ID WP_003050245.1
Coordinates 6079481..6079951 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA20_RS28565 (PALA20_05646) 6075347..6076072 - 726 WP_003050273.1 CBASS effector endonuclease NucC -
PALA20_RS28570 (PALA20_05647) 6076111..6077013 - 903 WP_003153640.1 CBASS oligonucleotide cyclase -
PALA20_RS28575 (PALA20_05648) 6077013..6077513 - 501 WP_003090159.1 type III CBASS phage resistance system CD-NTase-associated protein Cap7 -
PALA20_RS28580 (PALA20_05649) 6077510..6077980 - 471 WP_003090160.1 type III CBASS phage resistance system CD-NTase-associated protein Cap8 -
PALA20_RS28585 (PALA20_05650) 6077977..6078891 - 915 WP_003050256.1 AAA family ATPase -
PALA20_RS28590 (PALA20_05651) 6078909..6079484 - 576 WP_003153636.1 PIN domain-containing protein Toxin
PALA20_RS28595 (PALA20_05652) 6079481..6079951 - 471 WP_003050245.1 helix-turn-helix domain-containing protein Antitoxin
PALA20_RS28600 (PALA20_05653) 6080155..6080538 + 384 WP_003090167.1 RAQPRD family integrative conjugative element protein -
PALA20_RS28605 (PALA20_05654) 6080535..6080768 + 234 WP_003050225.1 TIGR03758 family integrating conjugative element protein -
PALA20_RS28610 (PALA20_05655) 6080785..6081144 + 360 WP_003153634.1 TIGR03745 family integrating conjugative element membrane protein -
PALA20_RS28615 (PALA20_05656) 6081157..6081555 + 399 WP_003105639.1 TIGR03750 family conjugal transfer protein -
PALA20_RS28620 (PALA20_05657) 6081552..6082244 + 693 WP_023100424.1 TIGR03746 family integrating conjugative element protein -
PALA20_RS28625 (PALA20_05658) 6082241..6083152 + 912 WP_269973235.1 TIGR03749 family integrating conjugative element protein -
PALA20_RS28630 (PALA20_05659) 6083142..6084560 + 1419 WP_023100422.1 TIGR03752 family integrating conjugative element protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 6037524..6165828 128304


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21629.78 Da        Isoelectric Point: 5.9995

>T260503 WP_003153636.1 NZ_CP107064:c6079484-6078909 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT260503 WP_003050245.1 NZ_CP107064:c6079951-6079481 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I3TV68

References