Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 4665680..4666901 | Replicon | chromosome |
Accession | NZ_CP107064 | ||
Organism | Pseudomonas aeruginosa strain PALA20 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | V6AG16 |
Locus tag | PALA20_RS22225 | Protein ID | WP_003088107.1 |
Coordinates | 4665680..4666258 (-) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | PALA20_RS22230 | Protein ID | WP_003088112.1 |
Coordinates | 4666347..4666901 (-) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PALA20_RS22210 (PALA20_04395) | 4660956..4662233 | + | 1278 | WP_003088104.1 | TolC family protein | - |
PALA20_RS22215 (PALA20_04396) | 4662223..4664394 | + | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
PALA20_RS22220 (PALA20_04397) | 4664384..4665571 | + | 1188 | WP_003088106.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
PALA20_RS22225 (PALA20_04398) | 4665680..4666258 | - | 579 | WP_003088107.1 | HD domain-containing protein | Toxin |
PALA20_RS22230 (PALA20_04399) | 4666347..4666901 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
PALA20_RS22235 (PALA20_04400) | 4667059..4669254 | - | 2196 | WP_003088114.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
PALA20_RS22240 (PALA20_04401) | 4669259..4669720 | - | 462 | WP_003088117.1 | (2Fe-2S)-binding protein | - |
PALA20_RS22245 (PALA20_04402) | 4670051..4670374 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
PALA20_RS22250 (PALA20_04403) | 4670387..4670785 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
PALA20_RS22255 (PALA20_04404) | 4670782..4671333 | - | 552 | WP_023098678.1 | XRE family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21885.74 Da Isoelectric Point: 5.3655
>T260502 WP_003088107.1 NZ_CP107064:c4666258-4665680 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT260502 WP_003088112.1 NZ_CP107064:c4666901-4666347 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|