Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4665680..4666901 Replicon chromosome
Accession NZ_CP107064
Organism Pseudomonas aeruginosa strain PALA20

Toxin (Protein)


Gene name vapC Uniprot ID V6AG16
Locus tag PALA20_RS22225 Protein ID WP_003088107.1
Coordinates 4665680..4666258 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PALA20_RS22230 Protein ID WP_003088112.1
Coordinates 4666347..4666901 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA20_RS22210 (PALA20_04395) 4660956..4662233 + 1278 WP_003088104.1 TolC family protein -
PALA20_RS22215 (PALA20_04396) 4662223..4664394 + 2172 WP_003088105.1 type I secretion system permease/ATPase -
PALA20_RS22220 (PALA20_04397) 4664384..4665571 + 1188 WP_003088106.1 HlyD family efflux transporter periplasmic adaptor subunit -
PALA20_RS22225 (PALA20_04398) 4665680..4666258 - 579 WP_003088107.1 HD domain-containing protein Toxin
PALA20_RS22230 (PALA20_04399) 4666347..4666901 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PALA20_RS22235 (PALA20_04400) 4667059..4669254 - 2196 WP_003088114.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PALA20_RS22240 (PALA20_04401) 4669259..4669720 - 462 WP_003088117.1 (2Fe-2S)-binding protein -
PALA20_RS22245 (PALA20_04402) 4670051..4670374 + 324 WP_003102734.1 multidrug efflux SMR transporter -
PALA20_RS22250 (PALA20_04403) 4670387..4670785 + 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PALA20_RS22255 (PALA20_04404) 4670782..4671333 - 552 WP_023098678.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-187)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21885.74 Da        Isoelectric Point: 5.3655

>T260502 WP_003088107.1 NZ_CP107064:c4666258-4665680 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDAKTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT260502 WP_003088112.1 NZ_CP107064:c4666901-4666347 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AG16

Antitoxin

Source ID Structure

References