Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1414967..1415472 Replicon chromosome
Accession NZ_CP107064
Organism Pseudomonas aeruginosa strain PALA20

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PALA20_RS06750 Protein ID WP_003083773.1
Coordinates 1415191..1415472 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PALA20_RS06745 Protein ID WP_003083775.1
Coordinates 1414967..1415194 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA20_RS06720 (PALA20_01336) 1409985..1411478 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
PALA20_RS06725 (PALA20_01337) 1411647..1413074 + 1428 WP_003083784.1 GABA permease -
PALA20_RS06730 (PALA20_01338) 1413156..1413497 - 342 WP_014603467.1 zinc ribbon domain-containing protein YjdM -
PALA20_RS06735 (PALA20_01339) 1413570..1414070 - 501 WP_003083778.1 LEA type 2 family protein -
PALA20_RS06740 (PALA20_01340) 1414171..1414791 + 621 WP_003101226.1 hypothetical protein -
PALA20_RS06745 (PALA20_01341) 1414967..1415194 + 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PALA20_RS06750 (PALA20_01342) 1415191..1415472 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PALA20_RS06755 (PALA20_01343) 1415772..1416680 + 909 WP_003083769.1 LysR family transcriptional regulator -
PALA20_RS06760 (PALA20_01344) 1416712..1417122 - 411 WP_003110659.1 aegerolysin family protein -
PALA20_RS06765 (PALA20_01345) 1417302..1418036 - 735 WP_003083764.1 GntR family transcriptional regulator -
PALA20_RS06770 (PALA20_01346) 1418137..1418823 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PALA20_RS06775 (PALA20_01347) 1418872..1420221 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T260499 WP_003083773.1 NZ_CP107064:1415191-1415472 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT260499 WP_003083775.1 NZ_CP107064:1414967-1415194 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References