Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 13296..13843 Replicon plasmid pMJ4-2
Accession NZ_CP107045
Organism Klebsiella pneumoniae strain KPTA-2108

Toxin (Protein)


Gene name parE Uniprot ID G7QEJ9
Locus tag OEC00_RS26930 Protein ID WP_001384452.1
Coordinates 13296..13574 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID F4V9S6
Locus tag OEC00_RS26935 Protein ID WP_000079931.1
Coordinates 13574..13843 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEC00_RS26895 (8991) 8991..9179 - 189 WP_001051770.1 hypothetical protein -
OEC00_RS26900 (9563) 9563..9853 - 291 Protein_9 integrase core domain-containing protein -
OEC00_RS26905 (9945) 9945..10708 + 764 Protein_10 IS3-like element IS2 family transposase -
OEC00_RS26910 (10843) 10843..11031 + 189 WP_130055808.1 hypothetical protein -
OEC00_RS26915 (11041) 11041..11295 + 255 Protein_12 transposase zinc-binding domain-containing protein -
OEC00_RS26920 (11385) 11385..11750 + 366 WP_001611636.1 hypothetical protein -
OEC00_RS26925 (11750) 11750..12937 + 1188 Protein_14 IS91 family transposase -
OEC00_RS26930 (13296) 13296..13574 - 279 WP_001384452.1 type II toxin-antitoxin system toxin YacB Toxin
OEC00_RS26935 (13574) 13574..13843 - 270 WP_000079931.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
OEC00_RS26940 (14753) 14753..15784 - 1032 WP_174785580.1 plasmid replication initiator RepA -
OEC00_RS26945 (16790) 16790..17020 + 231 WP_228772074.1 ash family protein -
OEC00_RS26950 (16938) 16938..17225 + 288 WP_000074849.1 conjugal transfer protein TraA -
OEC00_RS26955 (17667) 17667..18200 + 534 WP_174785581.1 transcription termination/antitermination NusG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..98026 98026


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10762.38 Da        Isoelectric Point: 8.4615

>T260492 WP_001384452.1 NZ_CP107045:c13574-13296 [Klebsiella pneumoniae]
MEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10194.55 Da        Isoelectric Point: 8.8735

>AT260492 WP_000079931.1 NZ_CP107045:c13843-13574 [Klebsiella pneumoniae]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CL36

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DLR5

References