Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3850583..3851334 Replicon chromosome
Accession NZ_CP107043
Organism Klebsiella pneumoniae strain KPTA-2108

Toxin (Protein)


Gene name ataT Uniprot ID H6U1U8
Locus tag OEC00_RS18815 Protein ID WP_014386536.1
Coordinates 3850852..3851334 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A071LPN3
Locus tag OEC00_RS18810 Protein ID WP_004902250.1
Coordinates 3850583..3850861 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEC00_RS18785 (3846234) 3846234..3846620 - 387 WP_063102497.1 bleomycin binding protein -
OEC00_RS18790 (3846814) 3846814..3847517 - 704 Protein_3667 IS6 family transposase -
OEC00_RS18795 (3847585) 3847585..3848883 + 1299 Protein_3668 Tn3-like element Tn3 family transposase -
OEC00_RS18800 (3849803) 3849803..3850144 + 342 WP_004902257.1 hypothetical protein -
OEC00_RS18805 (3850252) 3850252..3850464 + 213 WP_004902255.1 hypothetical protein -
OEC00_RS18810 (3850583) 3850583..3850861 + 279 WP_004902250.1 DUF1778 domain-containing protein Antitoxin
OEC00_RS18815 (3850852) 3850852..3851334 + 483 WP_014386536.1 GNAT family N-acetyltransferase Toxin
OEC00_RS18820 (3852369) 3852369..3852908 + 540 WP_004902239.1 hypothetical protein -
OEC00_RS18825 (3853013) 3853013..3853405 + 393 WP_032442757.1 hypothetical protein -
OEC00_RS18830 (3853506) 3853506..3854261 + 756 WP_004902235.1 DUF2971 domain-containing protein -
OEC00_RS18835 (3854288) 3854288..3854935 + 648 WP_014386537.1 EcsC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island qnrB4 / blaDHA-1 / sul1 / blaTEM-1B / rmtB / tet(G) / mph(E) / msr(E) / armA - 3821989..3896069 74080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17662.45 Da        Isoelectric Point: 8.9130

>T260487 WP_014386536.1 NZ_CP107043:3850852-3851334 [Klebsiella pneumoniae]
MGMRAPESLTAEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWAGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10704.23 Da        Isoelectric Point: 4.5271

>AT260487 WP_004902250.1 NZ_CP107043:3850583-3850861 [Klebsiella pneumoniae]
MKPDVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MBI1

Antitoxin

Source ID Structure
AlphaFold DB A0A071LPN3

References