Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3645952..3646723 Replicon chromosome
Accession NZ_CP107043
Organism Klebsiella pneumoniae strain KPTA-2108

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag OEC00_RS17760 Protein ID WP_186980539.1
Coordinates 3646334..3646723 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag OEC00_RS17755 Protein ID WP_186980561.1
Coordinates 3645952..3646278 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEC00_RS17725 (3641809) 3641809..3642897 + 1089 WP_065523308.1 patatin-like phospholipase family protein -
OEC00_RS17730 (3643033) 3643033..3643191 - 159 Protein_3458 transposase -
OEC00_RS17735 (3643864) 3643864..3644685 + 822 WP_065523307.1 DUF932 domain-containing protein -
OEC00_RS17740 (3644719) 3644719..3645168 + 450 WP_094545028.1 antirestriction protein -
OEC00_RS17745 (3645180) 3645180..3645659 + 480 WP_186980535.1 DNA repair protein RadC -
OEC00_RS17750 (3645673) 3645673..3645894 + 222 WP_186980537.1 DUF987 domain-containing protein -
OEC00_RS17755 (3645952) 3645952..3646278 + 327 WP_186980561.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OEC00_RS17760 (3646334) 3646334..3646723 + 390 WP_186980539.1 TA system toxin CbtA family protein Toxin
OEC00_RS17765 (3646810) 3646810..3647649 + 840 WP_186980541.1 DUF4942 domain-containing protein -
OEC00_RS17770 (3647990) 3647990..3649378 - 1389 WP_032420562.1 MFS transporter -
OEC00_RS17775 (3649508) 3649508..3650437 + 930 WP_048993420.1 LysR family transcriptional regulator -
OEC00_RS17780 (3650801) 3650801..3651604 - 804 WP_263598130.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3614574..3646723 32149


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14334.27 Da        Isoelectric Point: 8.5682

>T260486 WP_186980539.1 NZ_CP107043:3646334-3646723 [Klebsiella pneumoniae]
MQTKSSPLMRAASSHPSPVGVWQTLLTSLLEHHYGLTLSDTPFSDEQVIQQHIEAGISLADALNFIVEKYELVRTDRQGF
SIREQSPFITPIDILRARKATGLMNLGTYKDVTAITKGQHQQANTSGKR

Download         Length: 390 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12152.94 Da        Isoelectric Point: 7.3230

>AT260486 WP_186980561.1 NZ_CP107043:3645952-3646278 [Klebsiella pneumoniae]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDCQPVNADLRHLDQAFPVLMKQLELMLTSGELNPRHQHCVKLYA
KGLTCEADTLGSHGYVYIAIYPTPVATA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References