Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3605037..3605694 Replicon chromosome
Accession NZ_CP107043
Organism Klebsiella pneumoniae strain KPTA-2108

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OEC00_RS17560 Protein ID WP_002916310.1
Coordinates 3605284..3605694 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OEC00_RS17555 Protein ID WP_002916312.1
Coordinates 3605037..3605303 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEC00_RS17530 (3600193) 3600193..3601626 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
OEC00_RS17535 (3601745) 3601745..3602473 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OEC00_RS17540 (3602523) 3602523..3602834 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
OEC00_RS17545 (3602998) 3602998..3603657 + 660 WP_002916317.1 hemolysin III family protein -
OEC00_RS17550 (3603808) 3603808..3604791 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
OEC00_RS17555 (3605037) 3605037..3605303 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OEC00_RS17560 (3605284) 3605284..3605694 + 411 WP_002916310.1 protein YgfX Toxin
OEC00_RS17565 (3605701) 3605701..3606222 - 522 WP_004144730.1 flavodoxin FldB -
OEC00_RS17570 (3606323) 3606323..3607219 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OEC00_RS17575 (3607242) 3607242..3607955 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OEC00_RS17580 (3607961) 3607961..3609694 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T260485 WP_002916310.1 NZ_CP107043:3605284-3605694 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT260485 WP_002916312.1 NZ_CP107043:3605037-3605303 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References