Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2728529..2729154 Replicon chromosome
Accession NZ_CP107043
Organism Klebsiella pneumoniae strain KPTA-2108

Toxin (Protein)


Gene name vapC Uniprot ID A0A378FVD4
Locus tag OEC00_RS13235 Protein ID WP_019705794.1
Coordinates 2728529..2728912 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OEC00_RS13240 Protein ID WP_004150355.1
Coordinates 2728912..2729154 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEC00_RS13220 (2725895) 2725895..2726797 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OEC00_RS13225 (2726794) 2726794..2727429 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OEC00_RS13230 (2727426) 2727426..2728355 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OEC00_RS13235 (2728529) 2728529..2728912 - 384 WP_019705794.1 type II toxin-antitoxin system VapC family toxin Toxin
OEC00_RS13240 (2728912) 2728912..2729154 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OEC00_RS13245 (2729359) 2729359..2730276 + 918 WP_004146235.1 alpha/beta hydrolase -
OEC00_RS13250 (2730291) 2730291..2731232 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OEC00_RS13255 (2731277) 2731277..2731714 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OEC00_RS13260 (2731711) 2731711..2732571 - 861 WP_004146232.1 virulence factor BrkB family protein -
OEC00_RS13265 (2732565) 2732565..2733164 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14358.57 Da        Isoelectric Point: 6.8806

>T260483 WP_019705794.1 NZ_CP107043:c2728912-2728529 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT260483 WP_004150355.1 NZ_CP107043:c2729154-2728912 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378FVD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References