Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2386392..2388073 Replicon chromosome
Accession NZ_CP107043
Organism Klebsiella pneumoniae strain KPTA-2108

Toxin (Protein)


Gene name mosT Uniprot ID A0A483YLF8
Locus tag OEC00_RS11680 Protein ID WP_019724882.1
Coordinates 2386392..2387309 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag OEC00_RS11685 Protein ID WP_004177809.1
Coordinates 2387315..2388073 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEC00_RS11660 (2381698) 2381698..2383218 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
OEC00_RS11665 (2383215) 2383215..2384213 + 999 WP_002885172.1 ribose ABC transporter permease -
OEC00_RS11670 (2384244) 2384244..2385185 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OEC00_RS11675 (2385260) 2385260..2386267 + 1008 WP_064152101.1 carbohydrate kinase family protein -
OEC00_RS11680 (2386392) 2386392..2387309 - 918 WP_019724882.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OEC00_RS11685 (2387315) 2387315..2388073 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OEC00_RS11690 (2388159) 2388159..2388887 - 729 WP_002885152.1 response regulator transcription factor -
OEC00_RS11695 (2389160) 2389160..2391307 + 2148 WP_077625403.1 formate dehydrogenase subunit alpha -
OEC00_RS11700 (2391537) 2391537..2392223 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34653.14 Da        Isoelectric Point: 5.4707

>T260482 WP_019724882.1 NZ_CP107043:c2387309-2386392 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CITQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT260482 WP_004177809.1 NZ_CP107043:c2388073-2387315 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483YLF8

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References