Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2230915..2231431 Replicon chromosome
Accession NZ_CP107043
Organism Klebsiella pneumoniae strain KPTA-2108

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OEC00_RS10875 Protein ID WP_004178374.1
Coordinates 2230915..2231199 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OEC00_RS10880 Protein ID WP_002886901.1
Coordinates 2231189..2231431 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEC00_RS10850 (2226310) 2226310..2226618 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
OEC00_RS10855 (2226703) 2226703..2226876 + 174 WP_032412860.1 hypothetical protein -
OEC00_RS10860 (2226879) 2226879..2227622 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OEC00_RS10865 (2227979) 2227979..2230117 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OEC00_RS10870 (2230447) 2230447..2230911 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OEC00_RS10875 (2230915) 2230915..2231199 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OEC00_RS10880 (2231189) 2231189..2231431 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OEC00_RS10885 (2231509) 2231509..2233419 - 1911 WP_004152270.1 PRD domain-containing protein -
OEC00_RS10890 (2233442) 2233442..2234596 - 1155 WP_002886900.1 lactonase family protein -
OEC00_RS10895 (2234663) 2234663..2235403 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T260481 WP_004178374.1 NZ_CP107043:c2231199-2230915 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT260481 WP_002886901.1 NZ_CP107043:c2231431-2231189 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References