Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 184843..186431 Replicon chromosome
Accession NZ_CP107043
Organism Klebsiella pneumoniae strain KPTA-2108

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OEC00_RS00940 Protein ID WP_263598315.1
Coordinates 184843..186165 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OEC00_RS00945 Protein ID WP_004176198.1
Coordinates 186165..186431 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEC00_RS00925 (179899) 179899..182400 + 2502 WP_064151582.1 fimbria/pilus outer membrane usher protein -
OEC00_RS00930 (182388) 182388..183392 + 1005 WP_064151581.1 fimbrial protein -
OEC00_RS00935 (183534) 183534..184826 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OEC00_RS00940 (184843) 184843..186165 - 1323 WP_263598315.1 type II toxin-antitoxin system HipA family toxin Toxin
OEC00_RS00945 (186165) 186165..186431 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OEC00_RS00950 (186697) 186697..187023 - 327 WP_004176200.1 hydroxyisourate hydrolase -
OEC00_RS00955 (187020) 187020..187520 - 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OEC00_RS00960 (187498) 187498..188877 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
OEC00_RS00965 (189223) 189223..190377 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OEC00_RS00970 (190358) 190358..191281 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49194.50 Da        Isoelectric Point: 7.2850

>T260478 WP_263598315.1 NZ_CP107043:c186165-184843 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQVATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT260478 WP_004176198.1 NZ_CP107043:c186431-186165 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References