260475

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4650645..4651464 Replicon chromosome
Accession NZ_CP107040
Organism Klebsiella oxytoca strain TYL-T1

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag NQA44_RS21820 Protein ID WP_004110819.1
Coordinates 4651207..4651464 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag NQA44_RS21815 Protein ID WP_023320373.1
Coordinates 4650645..4651196 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQA44_RS21785 (NQA44_21785) 4646024..4646704 + 681 WP_023320375.1 nitroreductase -
NQA44_RS21790 (NQA44_21790) 4646712..4647914 - 1203 WP_032745597.1 multidrug effflux MFS transporter -
NQA44_RS21795 (NQA44_21795) 4648417..4648620 - 204 Protein_4287 VOC family protein -
NQA44_RS21800 (NQA44_21800) 4648620..4648829 - 210 WP_196089984.1 hypothetical protein -
NQA44_RS21805 (NQA44_21805) 4648999..4649763 - 765 WP_224226441.1 class I SAM-dependent methyltransferase -
NQA44_RS21810 (NQA44_21810) 4650157..4650531 - 375 Protein_4290 class I SAM-dependent methyltransferase -
NQA44_RS21815 (NQA44_21815) 4650645..4651196 - 552 WP_023320373.1 N-acetyltransferase Antitoxin
NQA44_RS21820 (NQA44_21820) 4651207..4651464 - 258 WP_004110819.1 YjhX family toxin Toxin
NQA44_RS21825 (NQA44_21825) 4652046..4653230 + 1185 WP_004099225.1 mannonate dehydratase -
NQA44_RS21830 (NQA44_21830) 4653305..4654780 + 1476 WP_004110817.1 fructuronate reductase -
NQA44_RS21835 (NQA44_21835) 4654916..4655692 + 777 WP_004099223.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(17-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T260475 WP_004110819.1 NZ_CP107040:c4651464-4651207 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20138.98 Da        Isoelectric Point: 6.8799

>AT260475 WP_023320373.1 NZ_CP107040:c4651196-4650645 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References