260474

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4387559..4388178 Replicon chromosome
Accession NZ_CP107040
Organism Klebsiella oxytoca strain TYL-T1

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag NQA44_RS20570 Protein ID WP_004099646.1
Coordinates 4387960..4388178 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NQA44_RS20565 Protein ID WP_004099648.1
Coordinates 4387559..4387933 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NQA44_RS20555 (NQA44_20555) 4382715..4383908 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NQA44_RS20560 (NQA44_20560) 4383931..4387077 + 3147 WP_263615965.1 multidrug efflux RND transporter permease subunit AcrB -
NQA44_RS20565 (NQA44_20565) 4387559..4387933 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
NQA44_RS20570 (NQA44_20570) 4387960..4388178 + 219 WP_004099646.1 HHA domain-containing protein Toxin
NQA44_RS20575 (NQA44_20575) 4388339..4388905 + 567 WP_023320460.1 maltose O-acetyltransferase -
NQA44_RS20580 (NQA44_20580) 4388874..4389011 - 138 WP_224226357.1 hypothetical protein -
NQA44_RS20585 (NQA44_20585) 4389042..4389512 + 471 WP_004111038.1 YlaC family protein -
NQA44_RS20590 (NQA44_20590) 4389487..4390941 - 1455 WP_023320459.1 PLP-dependent aminotransferase family protein -
NQA44_RS20595 (NQA44_20595) 4391043..4391741 + 699 WP_004099639.1 GNAT family protein -
NQA44_RS20600 (NQA44_20600) 4391738..4391878 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NQA44_RS20605 (NQA44_20605) 4391878..4392141 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T260474 WP_004099646.1 NZ_CP107040:4387960-4388178 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT260474 WP_004099648.1 NZ_CP107040:4387559-4387933 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References