Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1700169..1701085 Replicon chromosome
Accession NZ_CP107039
Organism Bacillus subtilis strain 11060

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag ODQ18_RS08765 Protein ID WP_003244695.1
Coordinates 1700169..1700915 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag ODQ18_RS08770 Protein ID WP_003232646.1
Coordinates 1700915..1701085 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ODQ18_RS08740 (1695251) 1695251..1695397 - 147 WP_120363335.1 hypothetical protein -
ODQ18_RS08745 (1695498) 1695498..1696448 - 951 WP_041344800.1 ring-cleaving dioxygenase -
ODQ18_RS08750 (1696836) 1696836..1698152 + 1317 WP_041850924.1 serine/threonine exchanger -
ODQ18_RS08755 (1698428) 1698428..1699045 + 618 WP_003218470.1 DUF47 domain-containing protein -
ODQ18_RS08760 (1699058) 1699058..1700059 + 1002 WP_003232642.1 inorganic phosphate transporter -
ODQ18_RS08765 (1700169) 1700169..1700915 + 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
ODQ18_RS08770 (1700915) 1700915..1701085 + 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
ODQ18_RS08775 (1701171) 1701171..1701308 + 138 WP_003232648.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
ODQ18_RS08780 (1701345) 1701345..1702238 - 894 WP_041850925.1 N-acetylmuramoyl-L-alanine amidase -
ODQ18_RS08785 (1702251) 1702251..1702514 - 264 WP_003232653.1 phage holin -
ODQ18_RS08790 (1702527) 1702527..1702796 - 270 WP_003232655.1 hemolysin XhlA family protein -
ODQ18_RS08795 (1702849) 1702849..1703688 - 840 WP_041850926.1 phage-like element PBSX protein XepA -
ODQ18_RS08800 (1703732) 1703732..1703896 - 165 WP_041850927.1 XkdX family protein -
ODQ18_RS08805 (1703893) 1703893..1704222 - 330 WP_041850928.1 XkdW family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T260466 WP_003244695.1 NZ_CP107039:1700169-1700915 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT260466 WP_003232646.1 NZ_CP107039:1700915-1701085 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References