Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1790177..1790845 Replicon chromosome
Accession NZ_CP107038
Organism Streptococcus pneumoniae strain BM6001

Toxin (Protein)


Gene name hicA Uniprot ID I0T4C6
Locus tag ODS73_RS09260 Protein ID WP_001132287.1
Coordinates 1790666..1790845 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag ODS73_RS09255 Protein ID WP_000961810.1
Coordinates 1790177..1790629 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ODS73_RS09230 (ODS73_09220) 1786069..1786812 - 744 WP_284060535.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
ODS73_RS09235 (ODS73_09225) 1786814..1787764 - 951 WP_000451152.1 50S ribosomal protein L11 methyltransferase -
ODS73_RS09240 (ODS73_09230) 1787900..1788328 - 429 WP_000418174.1 NUDIX hydrolase -
ODS73_RS09245 (ODS73_09235) 1788309..1789397 - 1089 WP_000719713.1 site-2 protease family protein -
ODS73_RS09250 (ODS73_09240) 1789416..1789886 - 471 WP_000257103.1 DUF3013 family protein -
ODS73_RS09255 (ODS73_09245) 1790177..1790629 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
ODS73_RS09260 (ODS73_09250) 1790666..1790845 - 180 WP_001132287.1 type II toxin-antitoxin system HicA family toxin Toxin
ODS73_RS09265 (ODS73_09255) 1790982..1791161 - 180 WP_001048906.1 hypothetical protein -
ODS73_RS09270 (ODS73_09260) 1791835..1793106 + 1272 WP_001113213.1 replication-associated recombination protein A -
ODS73_RS09280 (ODS73_09270) 1793652..1794971 - 1320 WP_050095773.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6697.91 Da        Isoelectric Point: 11.0174

>T260461 WP_001132287.1 NZ_CP107038:c1790845-1790666 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT260461 WP_000961810.1 NZ_CP107038:c1790629-1790177 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0T4C6

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References