Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1252024..1252522 Replicon chromosome
Accession NZ_CP107038
Organism Streptococcus pneumoniae strain BM6001

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ODS73_RS06405 Protein ID WP_001812387.1
Coordinates 1252024..1252278 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag ODS73_RS06410 Protein ID WP_000208080.1
Coordinates 1252280..1252522 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ODS73_RS06390 (ODS73_06385) 1247293..1249761 - 2469 WP_044811408.1 DNA gyrase subunit A -
ODS73_RS06395 (ODS73_06390) 1249955..1250941 + 987 WP_000204727.1 L-lactate dehydrogenase -
ODS73_RS06400 (ODS73_06395) 1251204..1251977 - 774 WP_044811410.1 ion channel -
ODS73_RS06405 (ODS73_06400) 1252024..1252278 - 255 WP_001812387.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ODS73_RS06410 (ODS73_06405) 1252280..1252522 - 243 WP_000208080.1 DUF6290 family protein Antitoxin
ODS73_RS06415 (ODS73_06410) 1252613..1253422 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
ODS73_RS06420 (ODS73_06415) 1253424..1254773 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
ODS73_RS06425 (ODS73_06420) 1254766..1255470 - 705 WP_000722076.1 response regulator YycF -
ODS73_RS06430 (ODS73_06425) 1255525..1256700 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.85 Da        Isoelectric Point: 10.7632

>T260460 WP_001812387.1 NZ_CP107038:c1252278-1252024 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT260460 WP_000208080.1 NZ_CP107038:c1252522-1252280 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References