Detailed information of TA system TA026046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/-
• Location: 1636542..1637064
• Accession: NC_016856
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: STM14_RS08605
• Protein ID: WP_000221343.1
• Coordinates: 1636542..1636826 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: STM14_RS08610
• Protein ID: WP_000885424.1
• Coordinates: 1636816..1637064 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
STM14_RS08585 (STM14_1865)	1632617..1634125	-	1509	WP_000199411.1	FAD-dependent oxidoreductase	-
STM14_RS08590 (STM14_1866)	1634170..1634658	+	489	WP_001293638.1	MarR family winged helix-turn-helix transcriptional regulator	-
STM14_RS08595 (STM14_1868)	1634851..1635930	+	1080	WP_000954688.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
STM14_RS08600 (STM14_1869)	1635982..1636371	-	390	WP_000194089.1	RidA family protein	-
STM14_RS08605 (STM14_1870)	1636542..1636826	-	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
STM14_RS08610 (STM14_1871)	1636816..1637064	-	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
STM14_RS08615 (STM14_1872)	1637216..1637431	+	216	WP_000206207.1	hypothetical protein	-
STM14_RS08620 (STM14_1873)	1637421..1637753	+	333	WP_000253154.1	DUF1493 family protein	-
STM14_RS08625 (STM14_1874)	1637896..1638804	+	909	WP_010989018.1	hypothetical protein	-
STM14_RS26005 (STM14_1875)	1638860..1639574	-	715	Protein_1576	helix-turn-helix domain-containing protein	-
STM14_RS08640 (STM14_1877)	1640382..1641848	-	1467	WP_000987828.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T26046 WP_000221343.1 NC_016856:c1636826-1636542 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T26046 NC_016856:c1636826-1636542 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT26046 WP_000885424.1 NC_016856:c1637064-1636816 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT26046 NC_016856:c1637064-1636816 [Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5