Detailed information of TA system TA260459

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1181738..1182984
• Replicon: chromosome
• Accession: NZ_CP107038
• Organism: Streptococcus pneumoniae strain BM6001

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: ODS73_RS06065
• Protein ID: WP_016399580.1
• Coordinates: 1182214..1182984 (+)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: B6ZCC4
• Locus tag: ODS73_RS06060
• Protein ID: WP_000579612.1
• Coordinates: 1181738..1182214 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ODS73_RS06035 (ODS73_06030)	1176848..1177096	+	249	WP_001814254.1	hypothetical protein	-
ODS73_RS06040 (ODS73_06035)	1177267..1177986	+	720	Protein_1194	type A chloramphenicol O-acetyltransferase	-
ODS73_RS06045 (ODS73_06040)	1178782..1179705	-	924	WP_000417606.1	protein rep	-
ODS73_RS06050 (ODS73_06045)	1179909..1180739	+	831	Protein_1196	alpha-amylase family glycosyl hydrolase	-
ODS73_RS06055 (ODS73_06050)	1181007..1181462	+	456	WP_025173400.1	hypothetical protein	-
ODS73_RS06060 (ODS73_06055)	1181738..1182214	+	477	WP_000579612.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
ODS73_RS06065 (ODS73_06060)	1182214..1182984	+	771	WP_016399580.1	type II toxin-antitoxin system toxin PezT	Toxin
ODS73_RS06070 (ODS73_06065)	1183240..1183923	+	684	WP_000492698.1	LexA family transcriptional regulator	-
ODS73_RS06075 (ODS73_06070)	1183926..1185341	+	1416	WP_000118333.1	Y-family DNA polymerase	-
ODS73_RS06080 (ODS73_06075)	1185341..1185703	+	363	WP_001082151.1	hypothetical protein	-
ODS73_RS06085 (ODS73_06080)	1185693..1185983	+	291	WP_001080184.1	DUF5960 family protein	-
ODS73_RS06090 (ODS73_06085)	1186278..1186634	+	357	WP_000827835.1	SAG1252 family conjugative relaxosome accessory protein	-
ODS73_RS06095 (ODS73_06090)	1186639..1187004	+	366	WP_000401236.1	MobC family plasmid mobilization relaxosome protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M) / cat(pC194)	-	1126641..1191345	64704

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29342.32 Da
• Isoelectric Point: 7.9440

>T260459 WP_016399580.1 NZ_CP107038:1182214-1182984 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTNRNGC

Nucleotide

• Length: 771 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18245.68 Da
• Isoelectric Point: 4.4188

>AT260459 WP_000579612.1 NZ_CP107038:1181738-1182214 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Antitoxin

• AlphaFold DB: B6ZCC4