Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 1174111..1175345 | Replicon | chromosome |
| Accession | NZ_CP107038 | ||
| Organism | Streptococcus pneumoniae strain BM6001 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | E6Y3Z8 |
| Locus tag | ODS73_RS06025 | Protein ID | WP_000405369.1 |
| Coordinates | 1174587..1175345 (+) | Length | 253 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | ODS73_RS06020 | Protein ID | WP_000579623.1 |
| Coordinates | 1174111..1174587 (+) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ODS73_RS05980 (ODS73_05975) | 1170368..1170652 | + | 285 | WP_000969641.1 | DUF5962 family protein | - |
| ODS73_RS05985 (ODS73_05980) | 1170666..1170962 | + | 297 | WP_000998891.1 | DUF5966 family protein | - |
| ODS73_RS05990 (ODS73_05985) | 1170976..1171173 | - | 198 | WP_004249782.1 | hypothetical protein | - |
| ODS73_RS05995 (ODS73_05990) | 1171333..1171974 | + | 642 | WP_050215983.1 | hypothetical protein | - |
| ODS73_RS06000 (ODS73_05995) | 1171984..1173069 | + | 1086 | WP_050215984.1 | toprim domain-containing protein | - |
| ODS73_RS06005 (ODS73_06000) | 1173120..1173353 | + | 234 | WP_000152419.1 | DUF5965 family protein | - |
| ODS73_RS06010 (ODS73_06005) | 1173350..1173733 | + | 384 | WP_000159212.1 | DUF5945 family protein | - |
| ODS73_RS06015 (ODS73_06010) | 1173771..1174043 | + | 273 | WP_000495438.1 | hypothetical protein | - |
| ODS73_RS06020 (ODS73_06015) | 1174111..1174587 | + | 477 | WP_000579623.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| ODS73_RS06025 (ODS73_06020) | 1174587..1175345 | + | 759 | WP_000405369.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| ODS73_RS06030 (ODS73_06025) | 1175821..1176609 | + | 789 | WP_000214003.1 | hypothetical protein | - |
| ODS73_RS06035 (ODS73_06030) | 1176848..1177096 | + | 249 | WP_001814254.1 | hypothetical protein | - |
| ODS73_RS06040 (ODS73_06035) | 1177267..1177986 | + | 720 | Protein_1194 | type A chloramphenicol O-acetyltransferase | - |
| ODS73_RS06045 (ODS73_06040) | 1178782..1179705 | - | 924 | WP_000417606.1 | protein rep | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | tet(M) / cat(pC194) | - | 1126641..1191345 | 64704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 253 a.a. Molecular weight: 28911.84 Da Isoelectric Point: 7.5459
>T260458 WP_000405369.1 NZ_CP107038:1174587-1175345 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
Download Length: 759 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18259.71 Da Isoelectric Point: 4.4258
>AT260458 WP_000579623.1 NZ_CP107038:1174111-1174587 [Streptococcus pneumoniae]
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|