Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3417000..3418221 | Replicon | chromosome |
| Accession | NZ_CP107029 | ||
| Organism | Pseudomonas aeruginosa strain PALA19 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | PALA19_RS16095 | Protein ID | WP_003114949.1 |
| Coordinates | 3417000..3417578 (-) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | PALA19_RS16100 | Protein ID | WP_003088112.1 |
| Coordinates | 3417667..3418221 (-) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PALA19_RS16080 (PALA19_03181) | 3412277..3413554 | + | 1278 | WP_003102743.1 | TolC family protein | - |
| PALA19_RS16085 (PALA19_03182) | 3413544..3415715 | + | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| PALA19_RS16090 (PALA19_03183) | 3415705..3416892 | + | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| PALA19_RS16095 (PALA19_03184) | 3417000..3417578 | - | 579 | WP_003114949.1 | HD domain-containing protein | Toxin |
| PALA19_RS16100 (PALA19_03185) | 3417667..3418221 | - | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| PALA19_RS16105 (PALA19_03186) | 3418379..3420574 | - | 2196 | WP_004349295.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| PALA19_RS16110 (PALA19_03187) | 3420579..3421040 | - | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| PALA19_RS16115 (PALA19_03188) | 3421371..3421694 | + | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| PALA19_RS16120 (PALA19_03189) | 3421707..3422105 | + | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| PALA19_RS16125 (PALA19_03190) | 3422102..3422653 | - | 552 | WP_004343115.1 | XRE family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21897.75 Da Isoelectric Point: 5.3655
>T260455 WP_003114949.1 NZ_CP107029:c3417578-3417000 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT260455 WP_003088112.1 NZ_CP107029:c3418221-3417667 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|