260454

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2494529..2495787 Replicon chromosome
Accession NZ_CP107029
Organism Pseudomonas aeruginosa strain PALA19

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag PALA19_RS11755 Protein ID WP_003112528.1
Coordinates 2495032..2495787 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PALA19_RS11750 Protein ID WP_003086329.1
Coordinates 2494529..2494897 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA19_RS11730 2490692..2490967 + 276 WP_010792073.1 zinc ribbon domain-containing protein -
PALA19_RS11735 (PALA19_02315) 2490970..2491446 - 477 WP_003112531.1 hypothetical protein -
PALA19_RS11740 (PALA19_02316) 2491525..2493114 + 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
PALA19_RS11745 (PALA19_02317) 2493170..2494456 + 1287 WP_003163134.1 FAD-binding oxidoreductase -
PALA19_RS11750 (PALA19_02318) 2494529..2494897 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PALA19_RS11755 (PALA19_02319) 2495032..2495787 + 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
PALA19_RS11760 (PALA19_02320) 2496555..2497916 + 1362 WP_073647918.1 DNA recombination protein RmuC -
PALA19_RS11765 (PALA19_02321) 2498071..2500614 - 2544 WP_003112526.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T260454 WP_003112528.1 NZ_CP107029:2495032-2495787 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT260454 WP_003086329.1 NZ_CP107029:2494529-2494897 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References