Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 621467..622104 Replicon chromosome
Accession NZ_CP107029
Organism Pseudomonas aeruginosa strain PALA19

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PALA19_RS02900 Protein ID WP_019725766.1
Coordinates 621467..621649 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PALA19_RS02905 Protein ID WP_019725767.1
Coordinates 621682..622104 (+) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA19_RS02880 618447..618590 + 144 WP_161566237.1 hypothetical protein -
PALA19_RS02885 (PALA19_00577) 618881..619216 - 336 WP_155687260.1 nuclease-related domain-containing protein -
PALA19_RS02890 (PALA19_00578) 619345..620466 - 1122 WP_003117952.1 Fic family protein -
PALA19_RS02895 620725..620862 - 138 WP_003113217.1 hypothetical protein -
PALA19_RS02900 (PALA19_00579) 621467..621649 + 183 WP_019725766.1 type II toxin-antitoxin system HicA family toxin Toxin
PALA19_RS02905 (PALA19_00580) 621682..622104 + 423 WP_019725767.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PALA19_RS02910 (PALA19_00582) 622350..623321 - 972 WP_033994831.1 hypothetical protein -
PALA19_RS02915 (PALA19_00583) 623306..623998 - 693 WP_031633726.1 hypothetical protein -
PALA19_RS02920 (PALA19_00584) 623995..624537 - 543 WP_025982284.1 hypothetical protein -
PALA19_RS02925 (PALA19_00585) 624534..625457 - 924 WP_124136263.1 hypothetical protein -
PALA19_RS02930 (PALA19_00586) 625454..625930 - 477 WP_109410360.1 phage tail assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 619345..674371 55026


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6970.07 Da        Isoelectric Point: 10.2954

>T260452 WP_019725766.1 NZ_CP107029:621467-621649 [Pseudomonas aeruginosa]
MKYSEFRRWLKARGVIFEPAKGSHFKVYYGDNQTIFPDHGAKEIGDGLRKKIIKDLGLKD

Download         Length: 183 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 14970.22 Da        Isoelectric Point: 4.9047

>AT260452 WP_019725767.1 NZ_CP107029:621682-622104 [Pseudomonas aeruginosa]
MFDYPVTVHEEAGSVWVSCDDVPEMASAGDTVDEALLDAVEGLESALSLYVDRRQSIPLPSKGKAGQSIVRLPALTSAKI
ALWNTMLAQNVGKAELARRLGVNRVQVDRLVDLLHGSKIEAVEHALAILGQRLAVTVIAA

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References