Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2584483..2585119 Replicon chromosome
Accession NZ_CP107027
Organism Cytobacillus firmus strain M7

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag OD459_RS13310 Protein ID WP_009336311.1
Coordinates 2584483..2584833 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W7L1R3
Locus tag OD459_RS13315 Protein ID WP_035331931.1
Coordinates 2584838..2585119 (-) Length 94 a.a.

Genomic Context

OD459_RS13335OD459_RS13275OD459_RS13280OD459_RS13285OD459_RS13290OD459_RS13295OD459_RS13300OD459_RS13305OD459_RS13310OD459_RS13315OD459_RS13320OD459_RS13325OD459_RS13330
Location: 2588922..2589647 (726 bp)
Type: Others
Protein ID: WP_163144744.1
Location: 2579854..2580648 (795 bp)
Type: Others
Protein ID: WP_048008774.1
Location: 2580626..2581099 (474 bp)
Type: Others
Protein ID: WP_009336304.1
Location: 2581096..2581428 (333 bp)
Type: Others
Protein ID: WP_035331808.1
Location: 2581489..2582499 (1011 bp)
Type: Others
Protein ID: WP_263599118.1
Location: 2582511..2582912 (402 bp)
Type: Others
Protein ID: WP_048008772.1
Location: 2582917..2583279 (363 bp)
Type: Others
Protein ID: WP_009336309.1
Location: 2583276..2584109 (834 bp)
Type: Others
Protein ID: WP_048008771.1
Location: 2584483..2584833 (351 bp)
Type: Toxin
Protein ID: WP_009336311.1
Location: 2584838..2585119 (282 bp)
Type: Antitoxin
Protein ID: WP_035331931.1
Location: 2585304..2586458 (1155 bp)
Type: Others
Protein ID: WP_258752060.1
Location: 2587257..2588270 (1014 bp)
Type: Others
Protein ID: WP_262177012.1
Location: 2588413..2588766 (354 bp)
Type: Others
Protein ID: WP_048008767.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
OD459_RS13275 (OD459_13275)2579854..2580648-795WP_048008774.1RNA polymerase sigma factor SigB-
OD459_RS13280 (OD459_13280)2580626..2581099-474WP_009336304.1anti-sigma B factor RsbW-
OD459_RS13285 (OD459_13285)2581096..2581428-333WP_035331808.1anti-sigma factor antagonist-
OD459_RS13290 (OD459_13290)2581489..2582499-1011WP_263599118.1PP2C family protein-serine/threonine phosphatase-
OD459_RS13295 (OD459_13295)2582511..2582912-402WP_048008772.1anti-sigma regulatory factor-
OD459_RS13300 (OD459_13300)2582917..2583279-363WP_009336309.1STAS domain-containing protein-
OD459_RS13305 (OD459_13305)2583276..2584109-834WP_048008771.1RsbT co-antagonist protein RsbRA-
OD459_RS13310 (OD459_13310)2584483..2584833-351WP_009336311.1type II toxin-antitoxin system endoribonuclease NdoAToxin
OD459_RS13315 (OD459_13315)2584838..2585119-282WP_035331931.1YlcI/YnfO family proteinAntitoxin
OD459_RS13320 (OD459_13320)2585304..2586458-1155WP_258752060.1alanine racemase-
OD459_RS13325 (OD459_13325)2587257..2588270-1014WP_262177012.1outer membrane lipoprotein carrier protein LolA-
OD459_RS13330 (OD459_13330)2588413..2588766-354WP_048008767.1holo-ACP synthase-
OD459_RS13335 (OD459_13335)2588922..2589647+726WP_163144744.1rhomboid family intramembrane serine protease-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T260450 WP_009336311.1 NZ_CP107027:c2584833-2584483 [Cytobacillus firmus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10831.33 Da        Isoelectric Point: 7.2028

>AT260450 WP_035331931.1 NZ_CP107027:c2585119-2584838 [Cytobacillus firmus]
VSESSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A169FD46

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBW7L1R3

References