Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2584483..2585119 Replicon chromosome
Accession NZ_CP107027
Organism Cytobacillus firmus strain M7

Toxin (Protein)


Gene name mazF Uniprot ID W7KPR3
Locus tag OD459_RS13310 Protein ID WP_009336311.1
Coordinates 2584483..2584833 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID W7L1R3
Locus tag OD459_RS13315 Protein ID WP_035331931.1
Coordinates 2584838..2585119 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OD459_RS13275 (OD459_13275) 2579854..2580648 - 795 WP_048008774.1 RNA polymerase sigma factor SigB -
OD459_RS13280 (OD459_13280) 2580626..2581099 - 474 WP_009336304.1 anti-sigma B factor RsbW -
OD459_RS13285 (OD459_13285) 2581096..2581428 - 333 WP_035331808.1 anti-sigma factor antagonist -
OD459_RS13290 (OD459_13290) 2581489..2582499 - 1011 WP_263599118.1 PP2C family protein-serine/threonine phosphatase -
OD459_RS13295 (OD459_13295) 2582511..2582912 - 402 WP_048008772.1 anti-sigma regulatory factor -
OD459_RS13300 (OD459_13300) 2582917..2583279 - 363 WP_009336309.1 STAS domain-containing protein -
OD459_RS13305 (OD459_13305) 2583276..2584109 - 834 WP_048008771.1 RsbT co-antagonist protein RsbRA -
OD459_RS13310 (OD459_13310) 2584483..2584833 - 351 WP_009336311.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OD459_RS13315 (OD459_13315) 2584838..2585119 - 282 WP_035331931.1 YlcI/YnfO family protein Antitoxin
OD459_RS13320 (OD459_13320) 2585304..2586458 - 1155 WP_258752060.1 alanine racemase -
OD459_RS13325 (OD459_13325) 2587257..2588270 - 1014 WP_262177012.1 outer membrane lipoprotein carrier protein LolA -
OD459_RS13330 (OD459_13330) 2588413..2588766 - 354 WP_048008767.1 holo-ACP synthase -
OD459_RS13335 (OD459_13335) 2588922..2589647 + 726 WP_163144744.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13006.03 Da        Isoelectric Point: 4.8998

>T260450 WP_009336311.1 NZ_CP107027:c2584833-2584483 [Cytobacillus firmus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEAVQISLGLIEF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10831.33 Da        Isoelectric Point: 7.2028

>AT260450 WP_035331931.1 NZ_CP107027:c2585119-2584838 [Cytobacillus firmus]
VSESSTTTEIMVKLPQHLLTELDGFAKQENVNRSEFIYQATKMYLRERKKRQIRESMRRGYMEMAKINLTIASEAFQAEY
EAEHTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A169FD46

Antitoxin

Source ID Structure
AlphaFold DB W7L1R3

References